PXD031209

PXD031209 is an original dataset announced via ProteomeXchange.

Title	Oxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy
Description	Hypoxia is a physiological stress that frequently occurs in solid tissues. Autophagy, a ubiquitous degradation/recycling system in eukaryotic cells, renders cells tolerant to multiple stressors. However, the mechanisms underlying autophagy initiation upon hypoxia remains unclear. This study identifies an oxygen-sensitive methylation of ULK1 with an important role in hypoxic stress adaptation by promoting autophagy induction.
HostingRepository	iProX
AnnounceDate	2022-01-25
AnnouncementXML	Submission_2022-10-08_23:51:19.834.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rui Liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue; dimethylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-24 21:18:27	ID requested
1	2022-01-25 19:19:19	announced
⏵ 2	2022-10-08 23:51:20	announced	2022-10-09: Update publication information.

Li J, Zhang T, Ren T, Liao X, Hao Y, Lim JS, Lee JH, Li M, Shao J, Liu R, Oxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy. Nat Commun, 13(1):1172(2022) [pubmed]

submitter keyword: ULK1 , hypoxia

Rui Liu
contact affiliation	Proteomics and Metabolomics Platform, the state key lab of oral diseases, Sichuan University
contact email	liurui_scu@hotmail.com
lab head
Rui Liu
contact affiliation	The state key lab of oral diseases, Sichuan University
contact email	liurui_scu@hotmail.com
dataset submitter

iProX dataset URI