PXD031162

PXD031162 is an original dataset announced via ProteomeXchange.

Title	Thermal proteome profiling of childhood ALL cell lines for proteoform detection
Description	Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and it has a 5-year survival rate of 85% for European children. But for subsets of patients who fail to respond to standard of care chemotherapeutics, treatment options are limited, and clinical prognosis is poor. To establish a novel platform and methodology to better characterize ALL subtypes and identify their pharmacologic vulnerabilities, we performed thermal proteome profiling of 20 childhood ALL cell lines.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:59:51.730.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rozbeh Jafari
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-21 13:07:51	ID requested
1	2023-03-21 16:16:56	announced
⏵ 2	2023-11-14 08:59:52	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: Proteoforms, TPP, CETSA,LC-MSMS, ALL

Rozbeh Jafari
contact affiliation	Karolinska Institutet, Department of Oncology-Pathology, Stockholm, Sweden.
contact email	rozbeh.jafari@ki.se
lab head
Rozbeh Jafari
contact affiliation	Karolinska Institutet
contact email	rozbeh.jafari@ki.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD031162

PRIDE project URI

• PRIDE
  1. PXD031162
     1. Label: PRIDE project
     2. Name: Thermal proteome profiling of childhood ALL cell lines for proteoform detection