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PXD031129

PXD031129 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics of human tau-transgenic mice reveals protein modules associated with tau pathologies
DescriptionAbnormally accumulated tau protein aggregates are one of the hallmarks of dementia, including Alzheimer’s disease (AD), and are believed to play a critical role in neurodegeneration. In order to investigate proteomic alteration driven by tau aggregates, we implemented quantitative proteomics to analyze disease model mice expressing human MAPTP301S transgene (hTau-Tg) and quantified more than 9,000 proteins in total. We applied the weighted gene co-expression analysis (WGCNA) algorithm to the datasets and explored protein co-expression modules that were associated with the accumulation of tau aggregates and were preserved in proteomes of AD brains. This led us to identify four modules with functions related to neuroinflammatory responses, mitochondrial energy production processes (including the tricarboxylic acid cycle and oxidative phosphorylation), cholesterol biosynthesis, and postsynaptic density. Furthermore, a phosphoproteomics study uncovered phosphorylation sites that were highly correlated with these modules. Our datasets represent resources for understanding the molecular basis of tau-induced neurodegeneration, including AD.
HostingRepositoryjPOST
AnnounceDate2022-07-05
AnnouncementXMLSubmission_2022-09-18_03:16:34.361.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKazuya Tsumagari
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListS-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide; O-phospho-L-serine; O-phospho-L-threonine; O4'-phospho-L-tyrosine
Instrumentinstrument
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-01-20 17:00:34ID requested
12022-08-04 23:57:18announced
22022-09-18 03:16:34announced2022-09-18: Updated FTP location.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Alzheimer’s disease / neurodegenerative disease / proteomics / tau / weighted gene co-expression network analysis
Contact List
Junro Kuromitsu
lab head
Kazuya Tsumagari
contact affiliationKeio University
dataset submitter
Full Dataset Link List
jPOST dataset URI
Dataset FTP location
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