PXD031107 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteogenomic analysis of relapsed acute myeloid leukemia in adults and children |
Description | Despite improvement of current treatment strategies and novel targeted drugs, relapse and treatment resistance determine the major cause of death for acute myeloid leukemia (AML) patients. To identify the underlying molecular characteristics, numerous studies have been aimed to decipher the genomic- and transcriptomic landscape of AML. Nevertheless, further molecular changes allowing malignant cells to escape treatment are yet to be elucidated. Mass spectrometry is a powerful tool enabling detailed insights into proteomic changes that could explain AML relapse and resistance. Here, we investigated AML samples from 47 adult and 22 pediatric patients at serial time-points during disease progression using high resolution isoelectric focusing liquid chromatography mass spectrometry. We show that the proteomic profile at relapse is enriched for mitochondrial ribosomal proteins and subunits of the respiratory chain complex, indicative of reprogrammed energy metabolism from diagnosis to relapse. Further, higher levels of granzymes and lower levels of the anti-inflammatory protein CR1/CD35 suggest an inflammatory signature promoting disease progression. Finally, through a proteogenomic approach, we detected novel peptides, which present a promising repertoire in the search for biomarkers and tumor-specific druggable targets. Altogether, this study highlights the importance of proteomic studies in holistic approaches to improve treatment and survival of AML patients. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:07:36.421.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Mattias Vesterlund |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-01-20 09:02:12 | ID requested | |
1 | 2023-01-09 18:51:45 | announced | |
⏵ 2 | 2023-11-14 08:07:37 | announced | 2023-11-14: Updated project metadata. |
Publication List
Stratmann S, Vesterlund M, Umer HM, Eshtad S, Skaftason A, Herlin MK, Sundstr, ö, m C, Eriksson A, H, ö, glund M, Palle J, Abrahamsson J, Jahnukainen K, Munthe-Kaas MC, Zeller B, Tamm KP, Lindskog C, Cavelier L, Lehti, ö J, Holmfeldt L, Proteogenomic analysis of acute myeloid leukemia associates relapsed disease with reprogrammed energy metabolism both in adults and children. Leukemia, 37(3):550-559(2023) [pubmed] |
Keyword List
submitter keyword: pediatric, Myeloblast, Human, LC-MS,Leukemia, Cancer, Proteogenomics, Clinical samples., HiRIEF, adult, Proteomics, Acute Myeloid Leukemia |
Contact List
Janne Lehtiö |
contact affiliation | Department of Oncology-Pathology, Karolinska Institutet and Science for Life Laboratory, Stockholm, Sweden |
contact email | janne.lehtio@ki.se |
lab head | |
Mattias Vesterlund |
contact affiliation | Karolinska Institutet |
contact email | mattias.vesterlund@ki.se |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD031107
- Label: PRIDE project
- Name: Proteogenomic analysis of relapsed acute myeloid leukemia in adults and children