PXD031066 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Differentiation of human induced pluripotent stem cells into induced motor neurons |
| Description | Characterisation of induced motor neurons (iMN) generated from human induced pluripotent stem cells (hiPSC, hPSCreg name BIHi005-A) using doxycycline inducible expression of Ngn2, Isl1 and Lhx3. While this method of iMN generation has been described before (REF: doi.org/10.1002/cpcb.51), no extensive characterisation of the transcriptome and proteome throughout the differentiation process or of the mature neurons has been undertaken so far. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-24 |
| AnnouncementXML | Submission_2025-11-23_19:00:29.002.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Tommaso Mari |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-01-19 02:39:49 | ID requested | |
| ⏵ 1 | 2025-11-23 19:00:30 | announced | |
Publication List
| 10.1093/narmme/ugaf005; |
| von K, ü, gelgen N, Ludwik K, Mendonsa S, R, ö, mer C, Becher E, Breimann L, Strauch M, Mari T, Mongellaz S, Zuckerman B, Efendic F, Grexa N, Oliveras-Martinez A, Woehler A, Selbach M, La Bella V, Ulitsky I, Chekulaeva M, -ALS iPSC model via axonal downregulation of neuromuscular junction proteins. NAR Mol Med, 2(2):ugaf005(2025) [pubmed] |
Keyword List
| submitter keyword: human induced pluripotent stem cells, hiPSC, iMN, induced motor neurons |
Contact List
| Matthias Selbach |
|---|
| contact affiliation | Proteome dynamics, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany |
| contact email | matthias.selbach@mdc-berlin.de |
| lab head | |
| Tommaso Mari |
|---|
| contact affiliation | Max Delbrück Center for Molecular Medicine - MDC |
| contact email | tommaso.mari@mdc-berlin.de |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD031066 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD031066
- Label: PRIDE project
- Name: Differentiation of human induced pluripotent stem cells into induced motor neurons
