PXD031050

PXD031050 is an original dataset announced via ProteomeXchange.

Title	Plasma proteomic profile by regular training in male and female basketball players: a preliminary study
Description	Aim of the present study is to identify sex-related sport adaptation proteins in female and male basketball players using proteomics approach on plasma samples withdraw from athletes during in-season training period but far from a competition. A cohort of 20 professional basketball players, 10 females (BF) and 10 males (BM), and 20 sedentary males (10 CM) and females (10 CF) as control, of comparable age and BMI were involved in this study. Protein profiles of plasma samples obtained from BM, BF, CM and CF were analysed by 2-DE. Differentially expressed proteins were identified by mass spectrometry. The computational 2-DE gel image analysis pointed out 33 differentially expressed protein spots (ANOVA p-value<0.05) and differences between male and female are more evident among the players than controls. The expression profile of 54.5% of the total proteins is affected by the sport activity. 14 proteins are differentially expressed in basket female players in comparison with their relative controls while 7 are differentially expressed in basket male players in comparison with their controls. In conclusion, we identify in female athletes a reduction in proteins related to transcription regulation, most of these modulate chronic inflammation confirming the anti-inflammatory effect of regular training in female muscle metabolism. In male and female athletes, we found a decrease in Transthyretin involved in muscle homeostasis and regeneration and Dermcidin a stress-induced myokine linked to inflammatory and it will be interesting to fully understand the role of its different isoforms in male and female skeletal muscle contraction.
HostingRepository	PRIDE
AnnounceDate	2024-10-08
AnnouncementXML	Submission_2024-10-08_11:16:24.363.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gabriella Pinto
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	6520A Quadrupole Time-of-Flight LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-18 02:19:15	ID requested
⏵ 1	2024-10-08 11:16:29	announced

10.3389/fphys.2022.813447;

Militello R, Pinto G, Illiano A, Luti S, Magherini F, Amoresano A, Modesti PA, Modesti A, Modulation of Plasma Proteomic Profile by Regular Training in Male and Female Basketball Players: A Preliminary Study. Front Physiol, 13():813447(2022) [pubmed]

submitter keyword: Regular training, sex differences,Plasma proteome, Basketball, Exerkines

Prof. Angela Amoresano
contact affiliation	Department of Chemical Science of University of Naples federico II
contact email	angela.amoresano@unina.it
lab head
Gabriella Pinto
contact affiliation	Department of chemical science University of Naples
contact email	gabriella.pinto@unina.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD031050

PRIDE project URI

• PRIDE
  1. PXD031050
     1. Label: PRIDE project
     2. Name: Plasma proteomic profile by regular training in male and female basketball players: a preliminary study