<<< Full experiment listing

PXD031050

PXD031050 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePlasma proteomic profile by regular training in male and female basketball players: a preliminary study
DescriptionAim of the present study is to identify sex-related sport adaptation proteins in female and male basketball players using proteomics approach on plasma samples withdraw from athletes during in-season training period but far from a competition. A cohort of 20 professional basketball players, 10 females (BF) and 10 males (BM), and 20 sedentary males (10 CM) and females (10 CF) as control, of comparable age and BMI were involved in this study. Protein profiles of plasma samples obtained from BM, BF, CM and CF were analysed by 2-DE. Differentially expressed proteins were identified by mass spectrometry. The computational 2-DE gel image analysis pointed out 33 differentially expressed protein spots (ANOVA p-value<0.05) and differences between male and female are more evident among the players than controls. The expression profile of 54.5% of the total proteins is affected by the sport activity. 14 proteins are differentially expressed in basket female players in comparison with their relative controls while 7 are differentially expressed in basket male players in comparison with their controls. In conclusion, we identify in female athletes a reduction in proteins related to transcription regulation, most of these modulate chronic inflammation confirming the anti-inflammatory effect of regular training in female muscle metabolism. In male and female athletes, we found a decrease in Transthyretin involved in muscle homeostasis and regeneration and Dermcidin a stress-induced myokine linked to inflammatory and it will be interesting to fully understand the role of its different isoforms in male and female skeletal muscle contraction.
HostingRepositoryPRIDE
AnnounceDate2024-10-08
AnnouncementXMLSubmission_2024-10-08_11:16:24.363.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGabriella Pinto
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
Instrument6520A Quadrupole Time-of-Flight LC/MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-01-18 02:19:15ID requested
12024-10-08 11:16:29announced
Publication List
10.3389/fphys.2022.813447;
Militello R, Pinto G, Illiano A, Luti S, Magherini F, Amoresano A, Modesti PA, Modesti A, Modulation of Plasma Proteomic Profile by Regular Training in Male and Female Basketball Players: A Preliminary Study. Front Physiol, 13():813447(2022) [pubmed]
Keyword List
submitter keyword: Regular training, sex differences,Plasma proteome, Basketball, Exerkines
Contact List
Prof. Angela Amoresano
contact affiliationDepartment of Chemical Science of University of Naples federico II
contact emailangela.amoresano@unina.it
lab head
Gabriella Pinto
contact affiliationDepartment of chemical science University of Naples
contact emailgabriella.pinto@unina.it
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD031050
PRIDE project URI
Repository Record List
[ + ]