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PXD031022

PXD031022 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNeurodegeneration and humoral response proteins in cerebrospinal fluid associate with pediatric-onset multiple sclerosis -- Validation
DescriptionThe pathogenesis of multiple sclerosis (MS) remains to be elucidated. Pediatric-onset MS (POMS) represents the earliest stage of the disease. CSF proteins in POMS may therefore provide causal information. Therefore, the aim of the current study was to analyze CSF proteins in children with an initial CNS acquired demyelinating syndrome (ADS) and to make a comparison between POMS and monophasic ADS (mADS). Patients were selected from two prospective pediatric ADS studies. Liquid chromatography-mass spectrometry was performed in a Dutch discovery cohort (POMS n=28; mADS n=39). Parallel reaction monitoring-mass spectrometry was performed on selected proteins more abundant in POMS with ≥ 8 unique peptides in a combined Dutch and Canadian validation cohort (POMS n=48; mADS n=106).
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:39:57.292.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD031022
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterChristoph Stingl
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList6x(13)C; 6x(13)C; monohydroxylated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-01-17 00:55:22ID requested
12024-10-07 13:45:02announced
22024-10-22 05:39:58announced2024-10-22: Updated project metadata.
Publication List
10.6019/PXD031022;
Bruijstens AL, Stingl C, G, ü, zel C, Stoop MP, Wong YYM, van Pelt ED, Banwell BL, Bar-Or A, Luider TM, Neuteboom RF, Neurodegeneration and humoral response proteins in cerebrospinal fluid associate with pediatric-onset multiple sclerosis and not monophasic demyelinating syndromes in childhood. Mult Scler, 29(1):52-62(2023) [pubmed]
10.1177/13524585221125369;
Keyword List
submitter keyword: proteomics, proteins, mass spectrometry,cerebrospinal fluid, multiple sclerosis, pediatrics
Contact List
Theo M. Luider
contact affiliationHead of Laboratory of Neuro-Oncology, Neurology, Clinical & Cancer Proteomics
contact emailt.luider@erasmusmc.nl
lab head
Christoph Stingl
contact affiliationErasmus MC Rotterdam Department of Neurology
contact emailc.stingl@erasmusmc.nl
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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