PXD031004

PXD031004 is an original dataset announced via ProteomeXchange.

Title	Neurodegeneration and humoral response proteins in cerebrospinal fluid associate with pediatric-onset multiple sclerosis -- Discovery
Description	The pathogenesis of multiple sclerosis (MS) remains to be elucidated. Pediatric-onset MS (POMS) represents the earliest stage of the disease. CSF proteins in POMS may therefore provide causal information. Therefore, the aim of the current study was to analyze CSF proteins in children with an initial CNS acquired demyelinating syndrome (ADS) and to make a comparison between POMS and monophasic ADS (mADS). Patients were selected from two prospective pediatric ADS studies. Liquid chromatography-mass spectrometry was performed in a Dutch discovery cohort (POMS n=28; mADS n=39). Parallel reaction monitoring-mass spectrometry was performed on selected proteins more abundant in POMS with ≥ 8 unique peptides in a combined Dutch and Canadian validation cohort (POMS n=48; mADS n=106).
HostingRepository	PRIDE
AnnounceDate	2022-09-30
AnnouncementXML	Submission_2022-09-30_12:05:58.964.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD031004
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Christoph Stingl
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-16 22:57:49	ID requested
⏵ 1	2022-09-30 12:05:59	announced

Bruijstens AL, Stingl C, G, ü, zel C, Stoop MP, Wong YYM, van Pelt ED, Banwell BL, Bar-Or A, Luider TM, Neuteboom RF, Neurodegeneration and humoral response proteins in cerebrospinal fluid associate with pediatric-onset multiple sclerosis and not monophasic demyelinating syndromes in childhood. Mult Scler, 29(1):52-62(2023) [pubmed]

submitter keyword: cerebrospinal fluid, proteins, proteomics, mass spectrometry, pediatrics, multiple sclerosis

Theo M. Luider
contact affiliation	Head of Laboratory of Neuro-Oncology, Neurology, Clinical & Cancer Proteomics
contact email	t.luider@erasmusmc.nl
lab head
Christoph Stingl
contact affiliation	Erasmus MC Rotterdam Department of Neurology
contact email	c.stingl@erasmusmc.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/09/PXD031004

PRIDE project URI

• PRIDE
  1. PXD031004
     1. Label: PRIDE project
     2. Name: Neurodegeneration and humoral response proteins in cerebrospinal fluid associate with pediatric-onset multiple sclerosis -- Discovery