PXD030952

PXD030952 is an original dataset announced via ProteomeXchange.

Title	Statin therapy inhibits Fatty Acid Synthase via dynamic protein modifications
Description	Recent discoveries revealed HMG-CoA is a reactive metabolite that can non-enzymatically modify proteins and impact their activity. Therefore, we predicted that inhibition of HMGCR by statins might increase HMG-CoA levels and protein modifications. Upon statin treatment, we observed a strong increase in HMG-CoA levels, and only a single protein was modified. Mass spectrometry revealed fatty acid synthase (FAS) was modified on active site residues and, importantly, the modification is located on non-lysine side-chains.
HostingRepository	PRIDE
AnnounceDate	2022-05-20
AnnouncementXML	Submission_2022-05-20_05:18:14.489.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alec Trub
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-14 00:46:41	ID requested
⏵ 1	2022-05-20 05:18:15	announced

Trub AG, Wagner GR, Anderson KA, Crown SB, Zhang GF, Thompson JW, Ilkayeva OR, Stevens RD, Grimsrud PA, Kulkarni RA, Backos DS, Meier JL, Hirschey MD, Statin therapy inhibits fatty acid synthase via dynamic protein modifications. Nat Commun, 13(1):2542(2022) [pubmed]

submitter keyword: Statin, Fatty Acid Synthase, HMGylation

Matthew D Hirschey
contact affiliation	Duke University Dept of Medicine
contact email	matthew.hirschey@duke.edu
lab head
Alec Trub
contact affiliation	Duke University
contact email	alec.trub@duke.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD030952

PRIDE project URI

• PRIDE
  1. PXD030952
     1. Label: PRIDE project
     2. Name: Statin therapy inhibits Fatty Acid Synthase via dynamic protein modifications