PXD030910

PXD030910 is an original dataset announced via ProteomeXchange.

Title	SARS-CoV-2 infects adipocytes in a fat depot- and viral strain-dependent manner
Description	Visceral adiposity is a risk factor for severe COVID-19 and a link between adipose tissue infection and disease progression has been proposed. Here we demonstrate that SARS-CoV-2 undergoes productive infection in adipocytes, although the degree of infection and the cellular response depend on the anatomical origin of the adipocyte and the viral strain. Differentiated adipocytes from human visceral adipose tissue are more permissive to SARS-CoV-2 infection than their subcutaneous counterpart, and this associates with ACE2 expression. Infection of subcutaneous adipocytes leads to inhibition of lipolysis, while infection of visceral adipocytes results in higher expression of pro-inflammatory cytokines. Infected adipocytes begin to die 4 days after infection, regardless of the origin. The viral load and cellular response are attenuated when adipocytes are infected with the SARS-CoV-2 variant P.1. Hence, SARS-CoV-2 infects and replicates in adipocytes, where it compromises cell viability and alters lipid metabolism or elicits a pro-inflammatory response depending on the fat depot and the viral strain.
HostingRepository	PRIDE
AnnounceDate	2024-02-29
AnnouncementXML	Submission_2024-02-29_11:12:44.788.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD030910
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Victor Corasolla Carregari
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-12 00:37:58	ID requested
⏵ 1	2024-02-29 11:12:45	announced

10.6019/PXD030910;

ProteomeXchange project tag: Sars-cov-2, Covid-19

submitter keyword: visceral adipocytes, inflammatory response, subcutaneous adipocytes,adipocytes, SARS-CoV-2 infection

Daniel Martins-de-Souza
contact affiliation	Department of Functional and Molecular Biology, Institute of Biology, State University of Campinas (UNICAMP), Brazil
contact email	dmsouza@unicamp.br
lab head
Victor Corasolla Carregari
contact affiliation	Post doctor
contact email	corasolla@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/02/PXD030910

PRIDE project URI

• PRIDE
  1. PXD030910
     1. Label: PRIDE project
     2. Name: SARS-CoV-2 infects adipocytes in a fat depot- and viral strain-dependent manner