PXD030883

PXD030883 is an original dataset announced via ProteomeXchange.

Title	Protein composition of circulating exosomes depend on tuberculosis disease state
Description	Tuberculosis (TB) is a contagious disease that is a primary cause of mortality and illness in around a quater of the world' population particular in low income nations. The disease most commonly affects lung, but pathogens can also be found in other parts of the body. Mycobacterium tuberculosis (Mtb) is the etiologic agent of TB and its ability to penetrate immune cells and develop a niche by beating the host's defense mechanism is crucial to its pathogenic sucess. Mtb has a diverse lipid and protein spectrum. Understanding the host-pathogen-interplay in active TB will have a substantial impact in understanding molecular mechanisms of Mtb infection and guide the development of vaccination, diagnostics and therapy response monitoring.
HostingRepository	PRIDE
AnnounceDate	2022-05-20
AnnouncementXML	Submission_2022-05-20_04:58:54.558.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD030883
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Johannes Schmidt
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-11 01:19:45	ID requested
⏵ 1	2022-05-20 04:58:55	announced

Biadglegne F, Schmidt JR, Engel KM, Lehmann J, Lehmann RT, Reinert A, K, ö, nig B, Schiller J, Kalkhof S, Sack U, Affects Protein and Lipid Content of Circulating Exosomes in Infected Patients Depending on Tuberculosis Disease State. Biomedicines, 10(4):(2022) [pubmed]

submitter keyword: exosomes, plasma, tuberculosis, mycobacterium tuberculosis, immunoglobulins, apolipoproteins

Prof. Dr. Stefan Kalkhof
contact affiliation	Fraunhofer Institute for Cell Therapy and Immunology IZI, Department Preclinical Development and Validation, Proteomics Unit, Leipzig, Germany
contact email	stefan.kalkhof@izi.fraunhofer.de
lab head
Johannes Schmidt
contact affiliation	Fraunhofer Institute for Cell Therapy and Immunology
contact email	johannes.schmidt@izi.fraunhofer.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD030883

PRIDE project URI

• PRIDE
  1. PXD030883
     1. Label: PRIDE project
     2. Name: Protein composition of circulating exosomes depend on tuberculosis disease state