PXD030814

PXD030814 is an original dataset announced via ProteomeXchange.

Title	PIP2 promotes MLKL-derived pathogenic process through enhancing its channel activity
Description	PIP2 enhances MLKL channel activity in a direct interaction manner and this gain of function promotes both necroptosis and inflammation. Previous studies have reported that phospholipids assisted MLKL recruitment and translocation which facilitates its mediated function like liposome leaking. Here, our result support MLKL act as ion channel and is finely tuned by PIP2. In the immune process especially, PIP2, as an important modulator, promotes intracellular potassium depletion and trigger inflammation which mediated bythrough MLKL channel function. Defining the role of MLKL channel function in MLKL-induced necroptosis or other potential necroptotic models will extend our understanding of the programmed cell death and critically inform the development and testing of new disease-specific, Anti-inflammatory, therapeutic strategies.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:46:30.220.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	jingbo qie
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-07 12:33:11	ID requested
1	2022-11-04 21:13:56	announced
⏵ 2	2023-11-14 07:46:34	announced	2023-11-14: Updated project metadata.

Xia B, Qie J, Shen X, Wang S, Gao Z, ignites MLKL-related pathogenic processes. Cell Discov, 8(1):111(2022) [pubmed]

submitter keyword: BV2 LPS MLKL LC/MSMS PIP2

Jingbo Qie
contact affiliation	Fudan University
contact email	jingboqie@fudan.edu.cn
lab head
jingbo qie
contact affiliation	Fudan University
contact email	jingboqie@fudan.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD030814

PRIDE project URI

• PRIDE
  1. PXD030814
     1. Label: PRIDE project
     2. Name: PIP2 promotes MLKL-derived pathogenic process through enhancing its channel activity