PXD030800
PXD030800 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma |
Description | The deregulation of alternative splicing (AS) has recently been implicated as a relevant source of molecular heterogeneity in cancer. However, the targets and intrinsic mechanisms on regulatory network of splicing in hepatocarcinogenesis are largely unknown. Here, we report a functional impact of the splice variant of Splicing Regulatory Glutamic Acid and Lysine Rich Protein 1 (SREK1) and its upstream regulator, Serine/arginine-rich splicing factor 10 (SRSF10) on sustaining the oncogenic signal. |
HostingRepository | PRIDE |
AnnounceDate | 2022-05-20 |
AnnouncementXML | Submission_2022-05-20_04:22:28.046.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Suat Peng Neo |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-01-07 02:37:23 | ID requested | |
⏵ 1 | 2022-05-20 04:22:28 | announced |
Publication List
Chang C, Rajasekaran M, Qiao Y, Dong H, Wang Y, Xia H, Deivasigamani A, Wu M, Sekar K, Gao H, Sun M, Niu Y, Li Q, Tao L, Yan Z, Wang M, Chen S, Zhao S, Chen D, Li L, Yang F, Gao H, Chen B, Su L, Xu L, Chen Y, Seshachalam VP, Chen G, Gunaratne J, Hong W, Shi J, Chen G, Grierson DS, Chabot B, Xie T, Hui KM, Chen J, The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma. Nat Commun, 13(1):1363(2022) [pubmed] |
Keyword List
submitter keyword: alternative splicing, SREK1, hepatocellular carcinoma, SRSF10, hepatocarcinogenesis, splicing factors, nonsense-mediated mRNA decay, BLOC1S5-TXNDC5 |
Contact List
Jayantha GUNARATNE | |
---|---|
contact affiliation | Translational Biomedical Proteomics, Institute of Molecular and Cell Biology (IMCB), Singapore |
contact email | jayanthag@imcb.a-star.edu.sg |
lab head | |
Suat Peng Neo | |
contact affiliation | Institute of Molecular and Cell Biology (ASTAR) |
contact email | neosp@imcb.a-star.edu.sg |
dataset submitter |
Full Dataset Link List
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PRIDE project URI |
Repository Record List
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