PXD030788

PXD030788 is an original dataset announced via ProteomeXchange.

Title	Study on the machanism of Tanshinone ⅡA Sulfonate in the treatment Cerebral Ischemic Stroke
Description	Cerebral ischemic stroke (CIS) has the characteristics of high prevalence, high recurrence rate, high disability rate and fatality rate. Sodium Tanshinone ⅡA Sulfonate (STS), as water-soluble substance after sulfonation of Tanshinone ⅡA, has a definite effect in the treatment of CIS, but the mechanism of it has not been fully elucidated.We employed DIA quantitative proteomics to analyze the protein expression in the ischemic penumbra of rats in each group, and screened the differential proteins according to the criteria of |log2FC|≥0.58 and p<0.05. R software was used to draw volcano maps and cluster analysis heat map, as well as STRING database to construct differential protein interaction (PPI) network. Then we performed GO enrichment analysis and KEGG signal pathway analysis with the aid of DAVID, ClueGO and other tools, and brought parallel reaction monitoring technology (PRM) method to detect protein expression.
HostingRepository	iProX
AnnounceDate	2022-01-07
AnnouncementXML	Submission_2022-01-06_20:35:21.587.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zheyi Wang
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-06 20:34:38	ID requested
⏵ 1	2022-01-06 20:35:21	announced

Dataset with its publication pending

submitter keyword: proteomics, Tanshinone ⅡA Sulfonate, Cerebral Ischemic Stroke, Autophagy

Tao Lu
contact affiliation	Beijing University of Chinese Medicine
contact email	861066896@qq.com
lab head
Zheyi Wang
contact affiliation	Beijing University of Chinese Medicine
contact email	zheyi91@126.com
dataset submitter

iProX dataset URI