PXD030787
PXD030787 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Evaluation of Acquired Antibiotic Resistance in Klebsiella pneumoniae Exposed to Short-Term Simulated Microgravity and Background Antibiotic Exposure |
| Description | Space flight missions last for a long time so bacterial infection during missions is considered a potential risk for astronauts. Studies of bacterial antibiotic resistance under spaceflight and simulated microgravity (SMG) have shown contrary results. To better understand the antibiotic stress resistance of K. pneumoniae in the microgravity environment, the original strain of K. pneumoniae (CGMCC 1.839), designated the KPO strain, was cultured under SMG conditions combined with background antibiotic exposure (SMGA) as the experimental group, while the control group was cultured in a NG environment without antibiotic exposure. After 20 cycles of incubation, the growth rate, antibiotic susceptibility, genomic , transcriptomic, and proteomic tests were conducted on the experimental and control groups designated the SMGA and NG strains, respectively. |
| HostingRepository | iProX |
| AnnounceDate | 2022-01-06 |
| AnnouncementXML | Submission_2022-01-06_20:31:01.492.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Tingzheng Fang |
| SpeciesList | scientific name: Klebsiella pneumoniae subsp. pneumoniae KPNIH1; NCBI TaxID: 1087440; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X; Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-01-06 20:30:19 | ID requested | |
| ⏵ 1 | 2022-01-06 20:31:01 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: simulated microgravity, antibiotic exposure, antibiotic resistant, K. pneumoniae, multiomic analysis |
Contact List
| Junfeng Wang | |
|---|---|
| contact affiliation | The Second Medical Center and National Clinical Research Center for Geriatric Disease, Chinese PLA General Hospital |
| contact email | wangjf72@hotmail.com |
| lab head | |
| Tingzheng Fang | |
| contact affiliation | Sixth Department of Health Care, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital |
| contact email | fangtingzheng2004@sina.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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