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PXD030781

PXD030781 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMurine Western diet-induced nonalcoholic steatohepatitis liver proteome
DescriptionNon-alcoholic fatty liver disease (NAFLD) is the number one cause of chronic liver disease worldwide, with 25% of these patients developing nonalcoholic steatohepatitis (NASH). NASH significantly increases the risk of cirrhosis and decompensated liver failure. Past studies in rodent models have shown the knockout of glycine-N-methyltransferase (GNMT) results in rapid pro-gression of steatosis, fibrosis, and hepatocellular carcinoma. However, the attenuation of GNMT in subjects with NASH and the molecular basis for its impact on the disease process are still unclear. To address this knowledge gap, we show the reduction of GNMT protein levels in the liver of NASH subjects compared to healthy controls. To gain insight into the impact of decreased GNMT in the disease process, we performed global label-free proteome studies on the livers from a murine Western diet-based model of NASH. Histological and molecular characterization of the animal model demonstrate high resemblance to the human disease.
HostingRepositoryPRIDE
AnnounceDate2022-05-25
AnnouncementXMLSubmission_2022-05-25_09:30:51.200.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD030781
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterConnor Quinn
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-01-06 01:49:51ID requested
12022-05-25 09:30:53announced
Publication List
Quinn C, Rico MC, Merali C, Merali S, Dysregulation of S-adenosylmethionine Metabolism in Nonalcoholic Steatohepatitis Leads to Polyamine Flux and Oxidative Stress. Int J Mol Sci, 23(4):(2022) [pubmed]
Keyword List
submitter keyword: Mouse, liver, LC-MS/MS, steatohepatitis
Contact List
Salim Merali
contact affiliationTemple University School of Pharmacy
contact emailsalim.merali@temple.edu
lab head
Connor Quinn
contact affiliationTemple University School of Pharmacy
contact emailconnor.quinn1@temple.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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