PXD030781

PXD030781 is an original dataset announced via ProteomeXchange.

Title	Murine Western diet-induced nonalcoholic steatohepatitis liver proteome
Description	Non-alcoholic fatty liver disease (NAFLD) is the number one cause of chronic liver disease worldwide, with 25% of these patients developing nonalcoholic steatohepatitis (NASH). NASH significantly increases the risk of cirrhosis and decompensated liver failure. Past studies in rodent models have shown the knockout of glycine-N-methyltransferase (GNMT) results in rapid pro-gression of steatosis, fibrosis, and hepatocellular carcinoma. However, the attenuation of GNMT in subjects with NASH and the molecular basis for its impact on the disease process are still unclear. To address this knowledge gap, we show the reduction of GNMT protein levels in the liver of NASH subjects compared to healthy controls. To gain insight into the impact of decreased GNMT in the disease process, we performed global label-free proteome studies on the livers from a murine Western diet-based model of NASH. Histological and molecular characterization of the animal model demonstrate high resemblance to the human disease.
HostingRepository	PRIDE
AnnounceDate	2022-05-25
AnnouncementXML	Submission_2022-05-25_09:30:51.200.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD030781
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Connor Quinn
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-06 01:49:51	ID requested
⏵ 1	2022-05-25 09:30:53	announced

Quinn C, Rico MC, Merali C, Merali S, Dysregulation of S-adenosylmethionine Metabolism in Nonalcoholic Steatohepatitis Leads to Polyamine Flux and Oxidative Stress. Int J Mol Sci, 23(4):(2022) [pubmed]

submitter keyword: Mouse, liver, LC-MS/MS, steatohepatitis

Salim Merali
contact affiliation	Temple University School of Pharmacy
contact email	salim.merali@temple.edu
lab head
Connor Quinn
contact affiliation	Temple University School of Pharmacy
contact email	connor.quinn1@temple.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD030781

PRIDE project URI

• PRIDE
  1. PXD030781
     1. Label: PRIDE project
     2. Name: Murine Western diet-induced nonalcoholic steatohepatitis liver proteome