PXD030781 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Murine Western diet-induced nonalcoholic steatohepatitis liver proteome |
Description | Non-alcoholic fatty liver disease (NAFLD) is the number one cause of chronic liver disease worldwide, with 25% of these patients developing nonalcoholic steatohepatitis (NASH). NASH significantly increases the risk of cirrhosis and decompensated liver failure. Past studies in rodent models have shown the knockout of glycine-N-methyltransferase (GNMT) results in rapid pro-gression of steatosis, fibrosis, and hepatocellular carcinoma. However, the attenuation of GNMT in subjects with NASH and the molecular basis for its impact on the disease process are still unclear. To address this knowledge gap, we show the reduction of GNMT protein levels in the liver of NASH subjects compared to healthy controls. To gain insight into the impact of decreased GNMT in the disease process, we performed global label-free proteome studies on the livers from a murine Western diet-based model of NASH. Histological and molecular characterization of the animal model demonstrate high resemblance to the human disease. |
HostingRepository | PRIDE |
AnnounceDate | 2022-05-25 |
AnnouncementXML | Submission_2022-05-25_09:30:51.200.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD030781 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Connor Quinn |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-01-06 01:49:51 | ID requested | |
⏵ 1 | 2022-05-25 09:30:53 | announced | |
Publication List
Quinn C, Rico MC, Merali C, Merali S, Dysregulation of S-adenosylmethionine Metabolism in Nonalcoholic Steatohepatitis Leads to Polyamine Flux and Oxidative Stress. Int J Mol Sci, 23(4):(2022) [pubmed] |
Keyword List
submitter keyword: Mouse, liver, LC-MS/MS, steatohepatitis |
Contact List
Salim Merali |
contact affiliation | Temple University School of Pharmacy |
contact email | salim.merali@temple.edu |
lab head | |
Connor Quinn |
contact affiliation | Temple University School of Pharmacy |
contact email | connor.quinn1@temple.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD030781
- Label: PRIDE project
- Name: Murine Western diet-induced nonalcoholic steatohepatitis liver proteome