PXD030753

PXD030753 is an original dataset announced via ProteomeXchange.

Title	The cGAS-STING pathway drives type I IFN immunopathology in COVID-19
Description	Syndrome Coronavirus 2 (SARS-CoV-2), is characterized by significant lung pathology and extrapulmonary complications. Type I interferons (IFNs) play an essential role in the pathogenesis of COVID-19. While rapid induction of type I IFNs limits virus propagation, sustained elevation of type I IFNs in the late phase of the infection is associated with aberrant inflammation and poor clinical outcome. Using proteomic data from a lung-on-chip model revealed that, in addition to macrophages, SARS-CoV-2 infection activates cGAS-STING signalling in endothelial cells through mitochondrial DNA release, leading to cell death and type I IFN production.
HostingRepository	PRIDE
AnnounceDate	2022-05-25
AnnouncementXML	Submission_2022-05-25_05:01:32.011.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vivek Thacker
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-05 13:07:23	ID requested
⏵ 1	2022-05-25 05:01:32	announced

Domizio JD, Gulen MF, Saidoune F, Thacker VV, Yatim A, Sharma K, Nass T, Guenova E, Schaller M, Conrad C, Goepfert C, de Leval L, Garnier CV, Berezowska S, Dubois A, Gilliet M, Ablasser A, The cGAS-STING pathway drives type I IFN immunopathology in COVID-19. Nature, 603(7899):145-151(2022) [pubmed]

submitter keyword: lung-on-chip, SARS-CoV-2, COVID-19, endothelial cells

Andrea Ablasser
contact affiliation	Global Health Institute EPFL Switzerland
contact email	andrea.ablasser@epfl.ch
lab head
Vivek Thacker
contact affiliation	Ecole Polytechnique Federale de Lausanne
contact email	vivekvthacker@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD030753

PRIDE project URI

• PRIDE
  1. PXD030753
     1. Label: PRIDE project
     2. Name: The cGAS-STING pathway drives type I IFN immunopathology in COVID-19