PXD030722
PXD030722 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ |
| Description | We used sTREM2 obtained from bacterial expression system to form a complex with Aβ40 fibrils in vitro. This complex was chemically cross-linked using two cross-linkers, BS3 and NHSF. |
| HostingRepository | iProX |
| AnnounceDate | 2022-01-05 |
| AnnouncementXML | Submission_2023-01-31_20:00:21.093.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Haifan Wu |
| SpeciesList | scientific name: Escherichia coli; NCBI TaxID: 562; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-01-05 00:30:12 | ID requested | |
| 1 | 2022-01-05 00:40:53 | announced | |
| 2 | 2022-10-09 23:57:41 | announced | 2022-10-10: Update publication information. |
| ⏵ 3 | 2023-01-31 20:00:22 | announced | 2022-10-10: Update publication information. 2023-02-01: Update publication information. |
Publication List
| Belsare KD, Wu H, Mondal D, Bond A, Castillo E, Jin J, Jo H, Roush AE, Pilla KB, Sali A, Condello C, DeGrado WF, . Proc Natl Acad Sci U S A, 119(5):(2022) [pubmed] |
Keyword List
| submitter keyword: Amyloid beta, sTREM2, cross-linking |
Contact List
| Bill DeGrado | |
|---|---|
| contact affiliation | University of California San Francisco |
| contact email | bill.degrado@ucsf.edu |
| lab head | |
| Haifan Wu | |
| contact affiliation | Wichita State University |
| contact email | haifan.wu@wichita.edu |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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