PXD030649
PXD030649 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Gut-mediated immune exhaustion increases vulnerability to sepsis during pregnancy |
| Description | Pregnancy appears to accelerate mortality associated with infectious diseases; however, the underlying mechanism of the crosstalk between pregnancy and sepsis remains poorly understood. Integrated multiomics analysis of gut microbiome revealed that the abundances of Parabacteroides merdae and its-derived formononetin (FMN) were decreased during pregnancy. Here, we verified that gut microbiota dysbiosis during pregnancy exacerbated immune exhaustion caused by sepsis through accelerating macrophage pyroptosis. Mechanistically, FMN suppressed nucleus-accumulation of hnRNPUL2 to prevent it from binding to Nlrp3 promoter region, thus to inhibit priming of NLRP3 inflammasome. Genetic knockdown of murine hnRNPUL2 by an adeno-associated virus protected against sepsis. Intriguingly, the abundances of Parabacteroides merdae and FMN in feces were negatively correlated with the progression of septic patients. Our data highlighted the significance of FMN/hnRNPUL2/NLRP3 axis mediated by dysbiosis of Parabacteroides merdae in immune exhaustion of pregnant septic hosts, shedding light on promising therapeutic strategies for the treatment of sepsis. |
| HostingRepository | iProX |
| AnnounceDate | 2021-12-27 |
| AnnouncementXML | Submission_2021-12-26_19:35:02.129.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Haihua Luo |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-12-26 19:34:55 | ID requested | |
| ⏵ 1 | 2021-12-26 19:35:02 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Sepsis, Pregnancy, Gut microbiota, formononetin, Immune exhaustion, hnRNPUL2 |
Contact List
| Shenhai Gong | |
|---|---|
| contact affiliation | School of Traditional Chinese Medicine, Southern Medical University |
| contact email | gsh0526@smu.edu.cn |
| lab head | |
| Haihua Luo | |
| contact affiliation | Southern Medical University |
| contact email | btxlhh@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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