PXD030647

PXD030647 is an original dataset announced via ProteomeXchange.

Title	Integrated Multilayer Omics Reveals the Genomic, Proteomic and Metabolic Influences of the Histidyl Dipeptides on Heart
Description	Histidyl dipeptides, such as carnosine, present in a micro-millimolar ranges in the heart, are synthesized via the enzyme carnosine synthase (Carns). These dipeptides facilitate glycolysis by proton buffering, form conjugates with reactive aldehydes, such as acrolein, and attenuate ischemia and reperfusion injury. While these dipeptides exhibit multifunctional properties, a composite understanding of their roles in myocardium is lacking. To identify the landscape of histidyl dipeptide mediated responses in the heart, we used a triomics approach of genome wide RNA sequencing, global proteomics and unbiased metabolomics in the cardio specific Carns transgenic (Tg) mice and integrated the three data sets.
HostingRepository	iProX
AnnounceDate	2021-12-25
AnnouncementXML	Submission_2022-10-10_21:44:12.458.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhanlong Mei
SpeciesList	scientific name: Mus ; NCBI TaxID: 10088;
ModificationList	S-carboxamidomethyl-L-cysteine
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-26 19:28:10	ID requested
1	2021-12-26 19:28:33	announced
⏵ 2	2022-10-10 21:44:13	announced	2022-10-11: Update publication information.

Yan K, Mei Z, Zhao J, Prodhan MAI, Obal D, Katragadda K, Doelling B, Hoetker D, Posa DK, He L, Yin X, Shah J, Pan J, Rai S, Lorkiewicz PK, Zhang X, Liu S, Bhatnagar A, Baba SP, Heart. J Am Heart Assoc, 11(13):e023868(2022) [pubmed]

submitter keyword: mouse heart, proteome, LC-MS

Siqi Liu
contact affiliation	Beijing Institute of Genomics
contact email	siqiliu@genomics.cn
lab head
Zhanlong Mei
contact affiliation	Beijing Institute of Genomics
contact email	meizhanlong@genomics.cn
dataset submitter

iProX dataset URI