PXD030629
PXD030629 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Deletion of smu.1558c gene affects growth and biofilm formation of Streptococcus mutans |
| Description | GCN5-related N-acetyltransferases (GNAT) family proteins are a diverse group of lysine acetyltransferases (KATs) widespread in bacteria. The members of this superfamily exhibited significant influences in many cellular processes, such as DNA binding, enzymatic activity, protein-protein interactions, protein stability, or protein localization. Streptococcus mutans is the crucial pathogen of human dental caries, however, the function of acetyltransferases in S. mutans remains unknown. In this study, we found that SMU.1558c, a member of the GNAT super-family, affects the growth rate, biofilm formation and extracellular polysaccharides (EPS) synthesis in S. mutans. When compared with the parental strain, a total of 166 differentially expressed proteins (DEPs) (>1.2-fold) were identified in the smu.1558c deletion mutant by global protein expression profiling. Bioinformatics analysis indicated that the DEPs were mainly related to protein homeostasis maintenance, carbohydrate metabolism and substances transporter systems. |
| HostingRepository | iProX |
| AnnounceDate | 2021-12-23 |
| AnnouncementXML | Submission_2021-12-23_19:35:37.861.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yang Chen |
| SpeciesList | scientific name: Streptococcus mutans UA159; NCBI TaxID: 210007; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-12-23 19:35:10 | ID requested | |
| ⏵ 1 | 2021-12-23 19:35:38 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Streptococcus mutans |
Contact List
| Yuqing Li | |
|---|---|
| contact affiliation | Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University |
| contact email | liyuqing@scu.edu.cn |
| lab head | |
| Yang Chen | |
| contact affiliation | State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University |
| contact email | drchenyang1994@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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