PXD030588

PXD030588 is an original dataset announced via ProteomeXchange.

Title	Antipsychotic cardiotoxicity and its mechanisms
Description	Antipsychotic (AP) drugs are common agents for treating mental disorders such as schizophrenia, bipolar disorder, and major depressive disorder. Overall AP prescription increased 3.8-fold, while second-generation AP (SGA) prescriptions increased 18.1-fold during a 16-year follow-up. The increased use of APs has led to public concern on the cardiac adverse effect, termed as cardiotoxicity, which is an uncommon but deadly effect, in addition to metabolic abnormalities. It has been estimated that long-term use of first-generation AP (FGA) and SGA drugs showed higher rates of sudden cardiac death than did nonusers of AP drugs, with adjusted incidence-rate ratios of 1.99 and 2.26, respectively. Despite extensive clinical concern on the AP drug safety, the rescue strategy has remained largely unchanged for years. When situated for AP drugs-induced dysrhythmia, administrative offices or clinicians usually withdraw or discontinue the offending drugs, a passive action that unfortunately leads to economic waste of on-the-market drugs. Therefore, in-depth investigation of APs cardiotoxicity with systemic evidence remains urgently needed.
HostingRepository	iProX
AnnounceDate	2021-12-22
AnnouncementXML	Submission_2022-07-19_20:30:28.377.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liliang Li
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	4800 Plus MALDI TOF/TOF

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-21 22:41:18	ID requested
1	2021-12-21 22:41:40	announced
⏵ 2	2022-07-19 20:30:29	announced	2022-07-20: Update publication information.

Li L, Gao P, Tang X, Liu Z, Cao M, Luo R, Li X, Wang J, Lin X, Peng C, Li Z, Zhang J, Zhang X, Cao Z, Zou Y, Jin L, CB1R-stabilized NLRP3 inflammasome drives antipsychotics cardiotoxicity. Signal Transduct Target Ther, 7(1):190(2022) [pubmed]

submitter keyword: antipsychotics, pyroptosis, cardiotoxicity

Liliang Li
contact affiliation	Fudan University
contact email	liliang_li@fudan.edu.cn
lab head
Liliang Li
contact affiliation	Fudan University
contact email	liliang_li@fudan.edu.cn
dataset submitter

iProX dataset URI