PXD030553

PXD030553 is an original dataset announced via ProteomeXchange.

Title	KMDR:K562 multi-drug resistance
Description	To understand the underlying resistance mechanisms in response to imatinib (IMA) and adriamycin (ADR), the parental K562 cells were treated with low doses of IMA or ADR for two months to generate derivative cells with mild, intermediate and severe resistance to the drugs as defined by their increasing resistance index (RI). PulseDIA-based quantitative proteomics was then employed to reveal the proteome changes in these resistant cells
HostingRepository	iProX
AnnounceDate	2021-12-21
AnnouncementXML	Submission_2023-02-20_19:17:21.232.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wei Liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-20 23:19:30	ID requested
1	2021-12-20 23:19:44	announced
⏵ 2	2023-02-20 19:17:22	announced	2023-02-21: Update information.

Liu W, Sun Y, Ge W, Zhang F, Gan L, Zhu Y, Guo T, Liu K, DIA-Based Proteomics Identifies IDH2 as a Targetable Regulator of Acquired Drug Resistance in Chronic Myeloid Leukemia. Mol Cell Proteomics, 21(2):100187(2022) [pubmed]

submitter keyword: pulseDIA, K562

Tiannan Guo
contact affiliation	Westlake University
contact email	Tiannan.guo@hotmail.com
lab head
Wei Liu
contact affiliation	Westlake University
contact email	wliu21@m.fudan.edu.cn
dataset submitter

iProX dataset URI