PXD030521

PXD030521 is an original dataset announced via ProteomeXchange.

Title	Aggregation as a host defense mechanism
Description	In this work, we hypothesized that the aggregation of proteins during wounding is a physiological host defense mechanism, which is triggered during pathogen invasion. Here, we demonstrate the ability of acute wound fluids (AWFs) to aggregate their protein content after exposer to bacterial endotoxins such as lipopolysaccharides (LPS). The composition of LPS-triggered aggregates clearly shows the enrichment of specific protein families, which are for example involved in the immune system, coagulation cascade, nuclear matrix, or lipid metabolism.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:05:42.887.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Charlotte Welinder
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-19 04:29:38	ID requested
1	2023-10-12 01:58:28	announced
2	2023-11-14 09:05:52	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 06:05:43	announced	2024-10-22: Updated project metadata.

10.1016/j.isci.2023.107951;

Petrlova J, Hartman E, Petruk G, Lim JCH, Adav SS, Kjellstr, ö, m S, Puthia M, Schmidtchen A, Selective protein aggregation confines and inhibits endotoxins in wounds: Linking host defense to amyloid formation. iScience, 26(10):107951(2023) [pubmed]

submitter keyword: Aggregation, LPS, innate immunity, proteins, inflammation, host defense, antimicrobial peptides

Jitka Petrlova
contact affiliation	Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-22184 Lund, Sweden
contact email	jitka.petrlova@med.lu.se
lab head
Charlotte Welinder
contact affiliation	Dept. of Oncology, Clinical Sciences, Lund University, 221 85 Lund, Sweden
contact email	charlotte.welinder@med.lu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD030521

PRIDE project URI

• PRIDE
  1. PXD030521
     1. Label: PRIDE project
     2. Name: Aggregation as a host defense mechanism