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PXD030521

PXD030521 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAggregation as a host defense mechanism
DescriptionIn this work, we hypothesized that the aggregation of proteins during wounding is a physiological host defense mechanism, which is triggered during pathogen invasion. Here, we demonstrate the ability of acute wound fluids (AWFs) to aggregate their protein content after exposer to bacterial endotoxins such as lipopolysaccharides (LPS). The composition of LPS-triggered aggregates clearly shows the enrichment of specific protein families, which are for example involved in the immune system, coagulation cascade, nuclear matrix, or lipid metabolism.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:05:42.887.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterCharlotte Welinder
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-12-19 04:29:38ID requested
12023-10-12 01:58:28announced
22023-11-14 09:05:52announced2023-11-14: Updated project metadata.
32024-10-22 06:05:43announced2024-10-22: Updated project metadata.
Publication List
10.1016/j.isci.2023.107951;
Petrlova J, Hartman E, Petruk G, Lim JCH, Adav SS, Kjellstr, รถ, m S, Puthia M, Schmidtchen A, Selective protein aggregation confines and inhibits endotoxins in wounds: Linking host defense to amyloid formation. iScience, 26(10):107951(2023) [pubmed]
Keyword List
submitter keyword: Aggregation, LPS, innate immunity, proteins, inflammation, host defense, antimicrobial peptides
Contact List
Jitka Petrlova
contact affiliationDivision of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-22184 Lund, Sweden
contact emailjitka.petrlova@med.lu.se
lab head
Charlotte Welinder
contact affiliationDept. of Oncology, Clinical Sciences, Lund University, 221 85 Lund, Sweden
contact emailcharlotte.welinder@med.lu.se
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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