PXD030506

PXD030506 is an original dataset announced via ProteomeXchange.

Title	Activated SUMOylation restricts the MHC class I antigen presentation pathway to confer immune evasion in cancer
Description	Activated SUMOylation is a hallmark of aggressive cancers. Starting from a targeted screening for SUMO-regulated immune evasion mechanisms, we identified an evolutionary conserved function of activated SUMOylation, which attenuates the immunogenicity of tumor cells. Activated SUMOylation allows cancer cells to evade CD8+ T-cell immunosurveillance by repressing the MHC-I antigen processing and presentation machinery (APM). While loss of the MHC-I APM is a frequent cause of resistance to cancer immunotherapies, the pharmacological inhibition of SUMOylation (SUMOi) restored the expression of the MHC-I APM and enhanced the susceptibility of tumor cells to CD8+ T-cell mediated killing. Importantly, SUMOi also triggered the activation of CD8+ T-cells itself and thereby drives a feed-forward loop amplifying the specific anti-tumor immune response. In summary, we show that activated SUMOylation converts tumor cells into a state of immune evasion, and identify SUMOi as rational therapeutic strategy for enhancing the efficacy of cancer immunotherapies.
HostingRepository	PRIDE
AnnounceDate	2022-01-15
AnnouncementXML	Submission_2022-01-15_07:07:39.194.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD030506
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Paul Hotz
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; sumoylated lysine
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-17 13:52:08	ID requested
⏵ 1	2022-01-15 07:07:39	announced

Dataset with its publication pending

submitter keyword: Human, B-Cell Lymphoma

Prof. Dr. Stefan Müller
contact affiliation	Institute of Biochemistry II, Goethe University Frankfurt, Medical School, 60590 Frankfurt, Germany
contact email	ste.mueller@em.uni-frankfurt.de
lab head
Paul Hotz
contact affiliation	Institute of Biochemistry II, Goethe University Medical School, University Hospital Building 75, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany
contact email	hotz@stud.uni-frankfurt.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD030506
     1. Label: PRIDE project
     2. Name: Activated SUMOylation restricts the MHC class I antigen presentation pathway to confer immune evasion in cancer