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PXD030506

PXD030506 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleActivated SUMOylation restricts the MHC class I antigen presentation pathway to confer immune evasion in cancer
DescriptionActivated SUMOylation is a hallmark of aggressive cancers. Starting from a targeted screening for SUMO-regulated immune evasion mechanisms, we identified an evolutionary conserved function of activated SUMOylation, which attenuates the immunogenicity of tumor cells. Activated SUMOylation allows cancer cells to evade CD8+ T-cell immunosurveillance by repressing the MHC-I antigen processing and presentation machinery (APM). While loss of the MHC-I APM is a frequent cause of resistance to cancer immunotherapies, the pharmacological inhibition of SUMOylation (SUMOi) restored the expression of the MHC-I APM and enhanced the susceptibility of tumor cells to CD8+ T-cell mediated killing. Importantly, SUMOi also triggered the activation of CD8+ T-cells itself and thereby drives a feed-forward loop amplifying the specific anti-tumor immune response. In summary, we show that activated SUMOylation converts tumor cells into a state of immune evasion, and identify SUMOi as rational therapeutic strategy for enhancing the efficacy of cancer immunotherapies.  
HostingRepositoryPRIDE
AnnounceDate2022-01-15
AnnouncementXMLSubmission_2022-01-15_07:07:39.194.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD030506
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterPaul Hotz
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; sumoylated lysine
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-12-17 13:52:08ID requested
12022-01-15 07:07:39announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Human, B-Cell Lymphoma
Contact List
Prof. Dr. Stefan Müller
contact affiliationInstitute of Biochemistry II, Goethe University Frankfurt, Medical School, 60590 Frankfurt, Germany
contact emailste.mueller@em.uni-frankfurt.de
lab head
Paul Hotz
contact affiliationInstitute of Biochemistry II, Goethe University Medical School, University Hospital Building 75, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany
contact emailhotz@stud.uni-frankfurt.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
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