PXD030506 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Activated SUMOylation restricts the MHC class I antigen presentation pathway to confer immune evasion in cancer |
Description | Activated SUMOylation is a hallmark of aggressive cancers. Starting from a targeted screening for SUMO-regulated immune evasion mechanisms, we identified an evolutionary conserved function of activated SUMOylation, which attenuates the immunogenicity of tumor cells. Activated SUMOylation allows cancer cells to evade CD8+ T-cell immunosurveillance by repressing the MHC-I antigen processing and presentation machinery (APM). While loss of the MHC-I APM is a frequent cause of resistance to cancer immunotherapies, the pharmacological inhibition of SUMOylation (SUMOi) restored the expression of the MHC-I APM and enhanced the susceptibility of tumor cells to CD8+ T-cell mediated killing. Importantly, SUMOi also triggered the activation of CD8+ T-cells itself and thereby drives a feed-forward loop amplifying the specific anti-tumor immune response. In summary, we show that activated SUMOylation converts tumor cells into a state of immune evasion, and identify SUMOi as rational therapeutic strategy for enhancing the efficacy of cancer immunotherapies. |
HostingRepository | PRIDE |
AnnounceDate | 2022-01-15 |
AnnouncementXML | Submission_2022-01-15_07:07:39.194.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD030506 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Paul Hotz |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; sumoylated lysine |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-12-17 13:52:08 | ID requested | |
⏵ 1 | 2022-01-15 07:07:39 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Human, B-Cell Lymphoma |
Contact List
Prof. Dr. Stefan Müller |
contact affiliation | Institute of Biochemistry II, Goethe University Frankfurt, Medical School, 60590 Frankfurt, Germany |
contact email | ste.mueller@em.uni-frankfurt.de |
lab head | |
Paul Hotz |
contact affiliation | Institute of Biochemistry II, Goethe University Medical School, University Hospital Building 75, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany |
contact email | hotz@stud.uni-frankfurt.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD030506
- Label: PRIDE project
- Name: Activated SUMOylation restricts the MHC class I antigen presentation pathway to confer immune evasion in cancer