PXD030464

PXD030464 is an original dataset announced via ProteomeXchange.

Title	The oncogene FOXQ1 is a selective activator of Wnt/β-catenin signalling
Description	The forkhead box transcription factor FOXQ1 is aberrantly induced in various cancers, and contributes to tumour growth and metastasis. It has been suggested that the oncogenic potential of FOXQ1 may be explained by its activation of the Wnt/β-catenin signalling pathway.However, the mode of action of FOXQ1 in the Wnt pathway remains to be resolved. Here we report that FOXQ1 is bimodal transcriptional activator of Wnt target gene expression in normal and cancer cells. Using co-immunoprecipitation, proximity proteomics, and reporter assays, we show that FOXQ1 engages the Wnt transcriptional complex to promote gene expressionvia TCF/LEF transcription factors.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:23:29.457.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD030464
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Lavanya Moparthi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-16 12:26:39	ID requested
1	2022-10-05 04:41:23	announced
⏵ 2	2023-11-14 08:23:30	announced	2023-11-14: Updated project metadata.

Pizzolato G, Moparthi L, S, ö, derholm S, Cant, ù C, Koch S, The oncogenic transcription factor FOXQ1 is a differential regulator of Wnt target genes. J Cell Sci, 135(19):(2022) [pubmed]

10.6019/PXD030464;

submitter keyword: Human, LC-MSMS

Stefan Koch
contact affiliation	Department of Biomedical and Clinical Sciences (BKV), Linköping University, SE-581 85,Linköping, Sweden; Wallenberg Centre for Molecular Medicine (WCMM), Linköping University, SE-581 85,Linköping, Sweden.
contact email	stefan.koch@liu.se
lab head
Lavanya Moparthi
contact affiliation	LINKÖPING UNIVERSITY
contact email	lavanya.moparthi@liu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD030464

PRIDE project URI

• PRIDE
  1. PXD030464
     1. Label: PRIDE project
     2. Name: The oncogene FOXQ1 is a selective activator of Wnt/β-catenin signalling