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PXD030464 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe oncogene FOXQ1 is a selective activator of Wnt/β-catenin signalling
DescriptionThe forkhead box transcription factor FOXQ1 is aberrantly induced in various cancers, and contributes to tumour growth and metastasis. It has been suggested that the oncogenic potential of FOXQ1 may be explained by its activation of the Wnt/β-catenin signalling pathway.However, the mode of action of FOXQ1 in the Wnt pathway remains to be resolved. Here we report that FOXQ1 is bimodal transcriptional activator of Wnt target gene expression in normal and cancer cells. Using co-immunoprecipitation, proximity proteomics, and reporter assays, we show that FOXQ1 engages the Wnt transcriptional complex to promote gene expressionvia TCF/LEF transcription factors.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterLavanya Moparthi
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-12-16 12:26:39ID requested
12022-10-05 04:41:23announced
Publication List
Pizzolato G, Moparthi L, S, ö, derholm S, Cant, ù C, Koch S, The oncogenic transcription factor FOXQ1 is a differential regulator of Wnt target genes. J Cell Sci, 135(19):(2022) [pubmed]
Keyword List
submitter keyword: Human, LC-MSMS
Contact List
Stefan Koch
contact affiliationDepartment of Biomedical and Clinical Sciences (BKV), Linköping University, SE-581 85,Linköping, Sweden; Wallenberg Centre for Molecular Medicine (WCMM), Linköping University, SE-581 85,Linköping, Sweden.
contact emailstefan.koch@liu.se
lab head
Lavanya Moparthi
contact affiliationLINKÖPING UNIVERSITY
contact emaillavanya.moparthi@liu.se
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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