PXD030426

PXD030426 is an original dataset announced via ProteomeXchange.

Title	Convergent Cerebrospinal Fluid Proteomes and Metabolic Ontologies in Humans and Animal Models of Rett Syndrome
Description	We measured the proteome of wild type and Mecp2 KO rat cerebral cortex, hippocampus and cerebrospinal fluid of animals aged 25 days postnatal age. We measured the proteome of human cerebrospinal fluid from Rett syndrome patients before and after treatment with recombinant IGF-1. We measured the proteome of wild type and Mecp2 KO as well as disease associated Mecp2 point mutations in LUHMEs dopaminergic postmitotic neurons. Project details can be found in doi: https://doi.org/10.1101/2021.11.30.470580
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:27:02.821.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD030426
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Aga Gambus
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-15 08:17:55	ID requested
1	2022-10-14 08:38:30	announced
⏵ 2	2023-11-14 08:27:05	announced	2023-11-14: Updated project metadata.

Zlatic SA, Duong D, Gadalla KKE, Murage B, Ping L, Shah R, Fink JJ, Khwaja O, Swanson LC, Sahin M, Rayaprolu S, Kumar P, Rangaraju S, Bird A, Tarquinio D, Carpenter R, Cobb S, Faundez V, Convergent cerebrospinal fluid proteomes and metabolic ontologies in humans and animal models of Rett syndrome. iScience, 25(9):104966(2022) [pubmed]

10.6019/PXD030426;

submitter keyword: RNA processing, manganese, parkinson's disease, parkinsonism, manganism, PARK2,SLC30A10

Victor Faunez
contact affiliation	Victor Faundez MD, PhD Professor Dept. Cell Biology 615 Michael Street Whitehead 446 Atlanta, GA, 30322 Emory University
contact email	vfaunde@emory.edu
lab head
Aga Gambus
contact affiliation	University of Birmingham
contact email	a.gambus@bham.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD030426

PRIDE project URI

• PRIDE
  1. PXD030426
     1. Label: PRIDE project
     2. Name: Convergent Cerebrospinal Fluid Proteomes and Metabolic Ontologies in Humans and Animal Models of Rett Syndrome