PXD030394

PXD030394 is an original dataset announced via ProteomeXchange.

Title	PFN4 is required for acrosome biogenesis by regulating autophagy through PI3K/AKT/mTOR pathway
Description	We generated Pfn4 knockout mice and showed that male mice are infertile and acrosome biogenesis is impaired from first phase of Development (Golgi-phase). Autophagy participates in acrosome formation and LC-MS data showed proteins related to autophagy, PI3K/AKT signaling and mTOR are enriched in PFN4-/- male mice.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:54:24.993.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD030394
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Marc Sylvester
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; S-carboxamidoethyl-L-cysteine; monohydroxylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-14 08:06:50	ID requested
1	2022-08-15 05:53:41	announced
⏵ 2	2023-11-14 08:54:25	announced	2023-11-14: Updated project metadata.

10.6019/PXD030394;

submitter keyword: Infertility , Autophagy, LC-MS, Mouse,Profilin 4

Hubert Schorle
contact affiliation	Department of Developmental Pathology, Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany
contact email	Hubert.Schorle@ukbonn.de
lab head
Marc Sylvester
contact affiliation	Institute of Biochemistry and Molecular Biology, Medical Faculty, University of Bonn
contact email	msylvest@uni-bonn.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD030394

PRIDE project URI

• PRIDE
  1. PXD030394
     1. Label: PRIDE project
     2. Name: PFN4 is required for acrosome biogenesis by regulating autophagy through PI3K/AKT/mTOR pathway