PXD030380

PXD030380 is an original dataset announced via ProteomeXchange.

Title	Proteomic dynamics in response to iron deficiency and hypoxia
Description	Iron and oxygen deficiencies are common features in pathophysiological conditions such as is-chemia, neurological diseases, and cancer. Cellular adaptive responses to such deficiencies include repression of mitochondrial respiration as well as promotion of angiogenesis and cell cycle con-trol. We applied a systematic proteomics analysis to determine the global proteomic changes caused by acute hypoxia, chronic and acute iron deficiency (ID) in hippocampal neuronal cells. Our analysis identified over 8600 proteins, revealing similar and differential effects of each treatment on activation and inhibition of pathways regulating neuronal development. In addition, com-parative analysis of ID-induced proteomics changes in cultured cells and transcriptomic changes in the rat hippocampus identified common altered pathways, indicating specific neuronal effects. Taken together, our study identified diverse signaling networks that were differentially regulated by hypoxia and ID in neuronal cells.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_06:21:17.875.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yue Chen
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-14 01:21:38	ID requested
⏵ 1	2022-02-17 06:21:18	announced

Erber L, Liu S, Gong Y, Tran P, Chen Y, Quantitative Proteome and Transcriptome Dynamics Analysis Reveals Iron Deficiency Response Networks and Signature in Neuronal Cells. Molecules, 27(2):(2022) [pubmed]

submitter keyword: Oxygen sensing, hypoxia, iron deficiency, quantitative proteomics, transcriptome analysis, neu-ronal cells, hippocampus

Yue Chen
contact affiliation	University of Minnesota at Twin Cities
contact email	yuechen@umn.edu
lab head
Yue Chen
contact affiliation	University of Minnesota
contact email	ychen2001@yahoo.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD030380

PRIDE project URI

• PRIDE
  1. PXD030380
     1. Label: PRIDE project
     2. Name: Proteomic dynamics in response to iron deficiency and hypoxia