PXD030369 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Omics-based analysis of honey bee (Apis mellifera) response to Varroa sp. interaction reveals changes impairing the winter bee generation |
Description | Extensive annual losses of honey bees (Apis mellifera L.) represent a global problem for agriculture and biodiversity. The parasitic mite Varroa destructor in association with viral co-infections plays a key role in this phenomenon; however, the precise mechanisms are still unclear. We employed a unique combination of transcriptomic, proteomic, metabolomic, and functional analyses to elucidate the effects of Varroa parasitisation. We focused on complex differences between parasitised and unparasitised ten-days old honey bee workers collected from identical colonies before overwintering. Honey bees exposed to mite parasitation during their development revealed alterations in transcriptome and proteome related to immunity, oxidative stress, olfactory recognition, metabolism of sphingolipids and RNA regulatory mechanisms. Specifically, immune reactions and sphingolipids metabolism were strongly up-regulated in parasitised honey bees; whereas olfactory recognition and oxidative stress pathways were down-regulated compared to unparasitised bees. Additionally, the metabolomic analysis confirmed the depletion of nutrients, decreased energy stores and generally disrupted metabolism of parasitised workers, as previously reported. By virtue of comprehensive omics-based analysis, we define the key changes in the honey bee facing Varroa parasitism and suggest possible mechanisms underlying its detrimental effects. This study provides a theoretical basis for future efforts in efficient control strategies against Varroa mites. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_06:46:27.254.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Rachel Ward |
SpeciesList | scientific name: Apis mellifera (Honeybee); NCBI TaxID: 7460; |
ModificationList | monohydroxylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-12-13 09:19:54 | ID requested | |
1 | 2023-06-23 01:31:27 | announced | |
⏵ 2 | 2023-11-14 06:46:27 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Apis mellifera, disease, proteomics, Varroa destructor |
Contact List
Kevin Kavanagh |
contact affiliation | Lab Head, Medical Mycology Lab |
contact email | kevin.kavanagh@mu.ie |
lab head | |
Rachel Ward |
contact affiliation | Maynooth Univeristy |
contact email | rachel.ward.2015@mumail.ie |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD030369
- Label: PRIDE project
- Name: Omics-based analysis of honey bee (Apis mellifera) response to Varroa sp. interaction reveals changes impairing the winter bee generation