PXD030329

PXD030329 is an original dataset announced via ProteomeXchange.

Title	Pig Enamel, Saliva and Serum Proteome
Description	Molar Hypomineralization is a developmental enamel defect, characterized by demarcated opacities, hypersensitivity, and soft enamel with elevated protein content. Excess protein in enamel, specifically albumin, not only arrests crystal growth during enamel development but also decreases the success rate of current restorative approaches. The development of targeted treatment options for MH is hampered by scarcity of available human samples to develop and test new treatment approaches. Additionally, there is still a need for an animal model mimicking the human MH phenotype in enamel composition and tooth size. We propose herein deciduous porcine enamel as a model for demarcated opacities in human enamel, based on its similarity in dimensions, mechanical properties, and, in particular, protein composition. In this project we aimed to characterize the distribution and developmental origins of albumin in porcine enamel.
HostingRepository	PRIDE
AnnounceDate	2024-01-26
AnnouncementXML	Submission_2024-01-26_05:48:28.739.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hakan karaaslan
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-12 05:20:52	ID requested
⏵ 1	2024-01-26 05:48:29	announced

10.3390/ijms242115577;

Gil-Bona A, Karaaslan H, Depalle B, Sulyanto R, Bidlack FB, Proteomic Analyses Discern the Developmental Inclusion of Albumin in Pig Enamel: A New Model for Human Enamel Hypomineralization. Int J Mol Sci, 24(21):(2023) [pubmed]

submitter keyword: enamel, saliva, serum proteomics,pig

Felicitas Bidlack
contact affiliation	The Forsyth Institute
contact email	fbidlack@forsyth.org
lab head
Hakan karaaslan
contact affiliation	Forsyth Institute
contact email	hakanka@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD030329

PRIDE project URI

• PRIDE
  1. PXD030329
     1. Label: PRIDE project
     2. Name: Pig Enamel, Saliva and Serum Proteome