PXD030303

PXD030303 is an original dataset announced via ProteomeXchange.

Title	Identification of disease biomarkers and potential endocrine factors in CoQ deficiency
Description	4-Hydroxybenzoic acid (4-HB) is the natural precursor for CoQ biosynthesis. Hydroxybenzoic acids derivatives (HBAs) have been recently used for the experimental treatment of primary CoQ deficiency. However, the mechanisms of these therapeutic effects remain obscure. In this study, we performed an analysis in plasma to evaluate the effect of supplementation with-resorcylic acid (-RA) or vanillic acid (VA), two HBAs potentially useful for the treatment of Coenzyme Q (CoQ) deficiencies, in an animal model of mitochondrial encephalopathy due to CoQ deficiency. The results help in the identification of potential biomarkers and/or endocrine factors that contribute to the pathophysiologic characteristics of the disease and its response to treatments, supporting important scientific and medical impacts for the use of -RA or VA in the treatment of CoQ deficiency.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:54:47.656.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Agustín Hidalgo Gutiérrez
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-11 15:17:12	ID requested
1	2022-07-15 07:22:17	announced
⏵ 2	2023-11-14 08:54:48	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

ProteomeXchange project tag: EPIC-XS

submitter keyword: 4-dihydroxybenzoic acid

plasma

mitochondria

C57BL/6,Vanillic Acid

-resorcylic acid

2

Luis Carlos López
contact affiliation	Departamento de Fisiología, Facultad de Medicina, Universidad de Granada, 18016 Granada, Spain
contact email	luisca@ugr.es
lab head
Agustín Hidalgo Gutiérrez
contact affiliation	University of Granada
contact email	Ahg@ugr.es
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD030303
     1. Label: PRIDE project
     2. Name: Identification of disease biomarkers and potential endocrine factors in CoQ deficiency