PXD030300

PXD030300 is an original dataset announced via ProteomeXchange.

Title	Amyloid peptide β-dependent loss of endothelial barrier function
Description	Alzheimer’s disease is the most common form of dementia and is associated with the accumulation of amyloid peptide β in the brain parenchyma. Vascular damage and microvascular thrombosis contribute to the neuronal degeneration and the loss of brain function typical of this disease. In this study, we utilised a murine model of Alzheimer’s disease to evaluate the neurovascular effects of this disease. Upon detection of an increase in the phosphorylation of the endothelial surface receptor VE-cadherin, we focused our attention on endothelial cells.
HostingRepository	PRIDE
AnnounceDate	2022-05-19
AnnouncementXML	Submission_2022-05-19_09:11:40.843.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD030300
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Christoph Krisp
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-11 15:11:29	ID requested
⏵ 1	2022-05-19 09:11:41	announced

Tarafdar A, Wolska N, Krisp C, Schl, ü, ter H, Pula G, disrupts intercellular junctions and increases endothelial permeability in a NADPH oxidase 1-dependent manner. Redox Biol, 52():102287(2022) [pubmed]

submitter keyword: Alzheimer’s disease, Amyloid peptide β, oxidative stress, hippocampus, endothelial barrier

Giordano Pula
contact affiliation	Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
contact email	g.pula@uke.de
lab head
Christoph Krisp
contact affiliation	University Medical Center Hamburg-Eppendorf Institute of Clinical Chemistry and Laboratory Medicine Mass Spectrometric Proteomics
contact email	c.krisp@uke.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD030300
     1. Label: PRIDE project
     2. Name: Amyloid peptide β-dependent loss of endothelial barrier function