PXD030254 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Quantitative phosphoproteomics study for assessing rodent thyroid toxicity |
Description | Here, we aimed to apply a TMT based quantitative phosphoproteomics approach to investigate rodent thyroid toxicity. For this purpose, male Wistar rats have been exposed to a direct (6-propyl-2-thiouracil, PTU) and an indirect (phenytoin) thyroid toxicant, respectively. Thereby, two doses (low:5ppm for PTU and 300ppm for phenytoin , high: 50ppm for PTU and 2400ppm for phenytoin) and three exposure time phase (short: 2 weeks, long:4 weeks, and long+recovery: 4weeks+2weeks) were investigated, allowing insights into the modes of action during thyroid toxicity. Phosphoproteomics were applied to liver. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-25 |
AnnouncementXML | Submission_2024-10-25_05:56:37.149.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD030254 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Zhipeng Wang |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-12-08 12:28:14 | ID requested | |
⏵ 1 | 2024-10-25 05:56:37 | announced | |
Publication List
Keyword List
submitter keyword: Phosphoproteomics, Liver, TMT,Thyroid toxicity, PTU, Phenytoin |
Contact List
Kristin Schubert |
contact affiliation | Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research GmbH – UFZ, 04318 Leipzig, Germany |
contact email | kristin.schubert@ufz.de |
lab head | |
Zhipeng Wang |
contact affiliation | Helmholtz Centre for Environmental Research |
contact email | zhipeng.wang@ufz.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD030254 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD030254
- Label: PRIDE project
- Name: Quantitative phosphoproteomics study for assessing rodent thyroid toxicity