PXD030239

PXD030239 is an original dataset announced via ProteomeXchange.

Title	Hypoxia-Induced Regulation of the Proteome in Multiple Myeloma Cell Lines
Description	Multiple myeloma (MM) is the second most common hematologic malignancy, which is characterized by clonal proliferation of neoplastic plasma cells in the bone marrow. This microenvironment is characterized by low oxygen levels (1-6% O2), known as hypoxia. For MM cells, hypoxia is a physiologic feature that has been described to promote an aggressive phenotype and to confer drug resistance. However, studies on hypoxia are scarce and show little conformity. Here, we analyzed the global proteome in MM cells and the stromal cell line HS-5 to reveal hypoxia-dependent regulation of proteins.
HostingRepository	PRIDE
AnnounceDate	2022-02-16
AnnouncementXML	Submission_2022-02-16_14:57:54.362.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Frank Schnütgen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-08 02:40:35	ID requested
⏵ 1	2022-02-16 14:57:55	announced

Clees AS, Stolp V, H, ä, upl B, Fuhrmann DC, Wempe F, Seibert M, Weber S, Banning A, Tikkanen R, Williams R, Br, ü, ne B, Serve H, Schn, ü, tgen F, von Metzler I, Kurrle N, Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene. Cells, 11(2):(2022) [pubmed]

submitter keyword: Human, Multiple Myeloma, Plasma Cells, Hypoxia, LC-MS/MS

Hubert Serve
contact affiliation	University Hospital Frankfurt, Goethe University Department of Medicine Hematology/Oncology Theodor-Stern-Kai 7 60590 Frankfurt am Main Germany
contact email	Hubert.Serve@kgu.de
lab head
Frank Schnütgen
contact affiliation	University Hospital Frankfurt, Goethe University Department of Medicine, Hematology/Oncology Theodor-Stern-Kai 7 60590 Frankfurt am Main
contact email	schnuetgen@em.uni-frankfurt.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD030239

PRIDE project URI

• PRIDE
  1. PXD030239
     1. Label: PRIDE project
     2. Name: Hypoxia-Induced Regulation of the Proteome in Multiple Myeloma Cell Lines