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PXD030237

PXD030237 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePhosphoproteomcs of the folliculin negative cancer cell line UOK257 +/- lentiviral rescue construct
DescriptionIn Birt-Hogg-Dubé (BHD) syndrome, germline mutations in the Folliculin (FLCN) gene lead to an increased risk of renal cancer. To address if FLCN is involved regulating cellular signaling pathways via protein and receptor phosphorylation we determined comprehensive phosphoproteomic profiles of FLCN-POS and FLCN-NEG human tumor cells (UOK257). UOK257 misses the folliculin (FLCN) gene, whereas UOK 257-2 harbours a lentiviral rescue of the FLCN gene. Experiment performed in duplicate. This data set is linked to PXD021346 that describes phosphoproteomics results for human renal tubular epithelial cells (RPTEC/TERT1).
HostingRepositoryPRIDE
AnnounceDate2022-07-11
AnnouncementXMLSubmission_2022-07-11_05:36:29.529.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSander Piersma
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-12-08 02:35:53ID requested
12022-07-11 05:36:29announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: FLCN, folliculin, phosphoproteomics, pTyrIP, IMAC, single shot, label free
Contact List
Connie Jimenez
contact affiliationAmsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands
contact emailc.jimenez@amsterdamumc.nl
lab head
Sander Piersma
contact affiliationAmsterdam UMC
contact emails.piersma@amsterdamumc.nl
dataset submitter
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Dataset FTP location
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PRIDE project URI
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