PXD030237 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Phosphoproteomcs of the folliculin negative cancer cell line UOK257 +/- lentiviral rescue construct |
Description | In Birt-Hogg-Dubé (BHD) syndrome, germline mutations in the Folliculin (FLCN) gene lead to an increased risk of renal cancer. To address if FLCN is involved regulating cellular signaling pathways via protein and receptor phosphorylation we determined comprehensive phosphoproteomic profiles of FLCN-POS and FLCN-NEG human tumor cells (UOK257). UOK257 misses the folliculin (FLCN) gene, whereas UOK 257-2 harbours a lentiviral rescue of the FLCN gene. Experiment performed in duplicate. This data set is linked to PXD021346 that describes phosphoproteomics results for human renal tubular epithelial cells (RPTEC/TERT1). |
HostingRepository | PRIDE |
AnnounceDate | 2022-07-11 |
AnnouncementXML | Submission_2022-07-11_05:36:29.529.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Sander Piersma |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-12-08 02:35:53 | ID requested | |
⏵ 1 | 2022-07-11 05:36:29 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: FLCN, folliculin, phosphoproteomics, pTyrIP, IMAC, single shot, label free |
Contact List
Connie Jimenez |
contact affiliation | Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands |
contact email | c.jimenez@amsterdamumc.nl |
lab head | |
Sander Piersma |
contact affiliation | Amsterdam UMC |
contact email | s.piersma@amsterdamumc.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
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[ - ]
- PRIDE
- PXD030237
- Label: PRIDE project
- Name: Phosphoproteomcs of the folliculin negative cancer cell line UOK257 +/- lentiviral rescue construct