PXD030180

PXD030180 is an original dataset announced via ProteomeXchange.

Title	Proteomics of KRAS mutated and non-transformed pancreas cells treated with ethanol
Description	The goal for this study was to determine the effects of ethanol on pancreas cells and examine how ethanol influences protein expression in non-transformed and mutant KRAS cells. We performed TMT-labeled proteomics of non-transformed (hTERT-HPNE E6/E7) and KRAS mutated (hTERT-HPNE E6/E7/K-RasG12D) human pancreas cell lines following 6 months of 100 mM ethanol treatment.
HostingRepository	PRIDE
AnnounceDate	2022-05-19
AnnouncementXML	Submission_2022-05-19_06:09:24.264.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Emalie Clement
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-05 04:32:36	ID requested
⏵ 1	2022-05-19 06:09:25	announced

Clement EJ, Law HC, Qiao F, Noe D, Trevino JG, Woods NT, Combined Alcohol Exposure and KRAS Mutation in Human Pancreatic Ductal Epithelial Cells Induces Proliferation and Alters Subtype Signatures Determined by Multi-Omics Analysis. Cancers (Basel), 14(8):(2022) [pubmed]

submitter keyword: Ethanol, KRAS, TMT, Pancreas

Nicholas T. Woods
contact affiliation	University of Nebraska Medical Center
contact email	nicholas.woods@unmc.edu
lab head
Emalie Clement
contact affiliation	UNMC
contact email	emalie.clement@unmc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD030180

PRIDE project URI

• PRIDE
  1. PXD030180
     1. Label: PRIDE project
     2. Name: Proteomics of KRAS mutated and non-transformed pancreas cells treated with ethanol