PXD030170 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mapping of TDP-43 ubiquitination and acetylation sites |
Description | TAR DNA binding protein of 43 kDa (TDP-43) forms aggregates in neurodegenerative diseases, particularly certain forms of frontotemporal dementia and amyotrophic lateral sclerosis. Pathological modifications of TDP-43 include proteolytic fragmentation, phosphorylation, and ubiquitinylation. In this study, we systematically mapped TDP-42 ubiquitination as well as acetylation sites. |
HostingRepository | PRIDE |
AnnounceDate | 2022-05-25 |
AnnouncementXML | Submission_2022-05-25_03:10:07.587.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD030170 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Johannes Gloeckner |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | ubiquitination signature dipeptidyl lysine; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-12-03 06:52:14 | ID requested | |
⏵ 1 | 2022-05-25 03:10:10 | announced | |
Publication List
Hans F, Eckert M, von Zweydorf F, Gloeckner CJ, Kahle PJ, Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43). J Biol Chem, 293(41):16083-16099(2018) [pubmed] |
Garcia Morato J, Hans F, von Zweydorf F, Feederle R, Els, ä, sser SJ, Skodras AA, Gloeckner CJ, Buratti E, Neumann M, Kahle PJ, Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43. Nat Commun, 13(1):1223(2022) [pubmed] |
Keyword List
submitter keyword: ubiquitination, acetylation, TDP-43 |
Contact List
Christian Johannes Gloeckner |
contact affiliation | German Center for Neurodegenerative Diseases (DZNE) Otfried-Müller-Strasse 23 72076 Tübingen Germany |
contact email | johannes.gloeckner@dzne.de |
lab head | |
Johannes Gloeckner |
contact affiliation | DZNE |
contact email | johannes.gloeckner@dzne.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD030170
- Label: PRIDE project
- Name: Mapping of TDP-43 ubiquitination and acetylation sites