PXD030170

PXD030170 is an original dataset announced via ProteomeXchange.

Title	Mapping of TDP-43 ubiquitination and acetylation sites
Description	TAR DNA binding protein of 43 kDa (TDP-43) forms aggregates in neurodegenerative diseases, particularly certain forms of frontotemporal dementia and amyotrophic lateral sclerosis. Pathological modifications of TDP-43 include proteolytic fragmentation, phosphorylation, and ubiquitinylation. In this study, we systematically mapped TDP-42 ubiquitination as well as acetylation sites.
HostingRepository	PRIDE
AnnounceDate	2022-05-25
AnnouncementXML	Submission_2022-05-25_03:10:07.587.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD030170
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Johannes Gloeckner
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	ubiquitination signature dipeptidyl lysine; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-03 06:52:14	ID requested
⏵ 1	2022-05-25 03:10:10	announced

Hans F, Eckert M, von Zweydorf F, Gloeckner CJ, Kahle PJ, Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43). J Biol Chem, 293(41):16083-16099(2018) [pubmed]

Garcia Morato J, Hans F, von Zweydorf F, Feederle R, Els, ä, sser SJ, Skodras AA, Gloeckner CJ, Buratti E, Neumann M, Kahle PJ, Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43. Nat Commun, 13(1):1223(2022) [pubmed]

submitter keyword: ubiquitination, acetylation, TDP-43

Christian Johannes Gloeckner
contact affiliation	German Center for Neurodegenerative Diseases (DZNE) Otfried-Müller-Strasse 23 72076 Tübingen Germany
contact email	johannes.gloeckner@dzne.de
lab head
Johannes Gloeckner
contact affiliation	DZNE
contact email	johannes.gloeckner@dzne.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD030170

PRIDE project URI

• PRIDE
  1. PXD030170
     1. Label: PRIDE project
     2. Name: Mapping of TDP-43 ubiquitination and acetylation sites