PXD030164 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Regulation of cellular proteome and acetylome by catalytic and non-catalytic functions of class I histone deacetylases |
Description | Project description: Taking advantage of a newly generated model system, we examined the influence of class I HDAC catalytic and non-catalytic function on the cellular proteome and acetylome. Therefore, we generated HAP1 cell lines either lacking individual class I HDACs or expressing catalytically inactive isoforms. Using these cell lines, we investigated whether deletion or inactivation of specific class I HDACs better mimics inhibitor treated cells using isobaric labeling (TMTpro). |
HostingRepository | PRIDE |
AnnounceDate | 2023-04-13 |
AnnouncementXML | Submission_2023-04-13_09:11:36.718.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | MarkusHartl |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-12-03 04:54:51 | ID requested | |
1 | 2022-08-16 03:10:14 | announced | |
⏵ 2 | 2023-04-13 09:11:38 | announced | 2023-04-13: Updated project metadata. |
Publication List
Keyword List
submitter keyword: acetylome,Chromatin, HDAC inhibitor, histone deacetylase |
Contact List
ChristianSeiser |
contact affiliation | Medical University of Vienna, Center for Anatomy and Cell Biology, Division for Cell and Developmental Biology, Vienna, Austria |
contact email | christian.seiser@meduniwien.ac.at |
lab head | |
MarkusHartl |
contact affiliation | Mass Spectrometry Facility, Max Perutz Labs Vienna, University of Vienna, Vienna Biocenter, Dr.-Bohr-Gasse 7, 1030 Vienna |
contact email | markus.hartl@univie.ac.at |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD030164
- Label: PRIDE project
- Name: Regulation of cellular proteome and acetylome by catalytic and non-catalytic functions of class I histone deacetylases