PXD030164

PXD030164 is an original dataset announced via ProteomeXchange.

Title	Regulation of cellular proteome and acetylome by catalytic and non-catalytic functions of class I histone deacetylases
Description	Project description: Taking advantage of a newly generated model system, we examined the influence of class I HDAC catalytic and non-catalytic function on the cellular proteome and acetylome. Therefore, we generated HAP1 cell lines either lacking individual class I HDACs or expressing catalytically inactive isoforms. Using these cell lines, we investigated whether deletion or inactivation of specific class I HDACs better mimics inhibitor treated cells using isobaric labeling (TMTpro).
HostingRepository	PRIDE
AnnounceDate	2023-04-13
AnnouncementXML	Submission_2023-04-13_09:11:36.718.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	MarkusHartl
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-03 04:54:51	ID requested
1	2022-08-16 03:10:14	announced
⏵ 2	2023-04-13 09:11:38	announced	2023-04-13: Updated project metadata.

Hess L, Moos V, Lauber AA, Reiter W, Schuster M, Hartl N, Lackner D, Boenke T, Koren A, Guzzardo PM, Gundacker B, Riegler A, Vician P, Miccolo C, Leiter S, Chandrasekharan MB, Vcelkova T, Tanzer A, Jun JQ, Bradner J, Brosch G, Hartl M, Bock C, B, ü, rckst, ü, mmer T, Kubicek S, Chiocca S, Bhaskara S, Seiser C, A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation. PLoS Genet, 18(8):e1010376(2022) [pubmed]

submitter keyword: acetylome,Chromatin, HDAC inhibitor, histone deacetylase

ChristianSeiser
contact affiliation	Medical University of Vienna, Center for Anatomy and Cell Biology, Division for Cell and Developmental Biology, Vienna, Austria
contact email	christian.seiser@meduniwien.ac.at
lab head
MarkusHartl
contact affiliation	Mass Spectrometry Facility, Max Perutz Labs Vienna, University of Vienna, Vienna Biocenter, Dr.-Bohr-Gasse 7, 1030 Vienna
contact email	markus.hartl@univie.ac.at
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD030164

PRIDE project URI

• PRIDE
  1. PXD030164
     1. Label: PRIDE project
     2. Name: Regulation of cellular proteome and acetylome by catalytic and non-catalytic functions of class I histone deacetylases