PXD030161

PXD030161 is an original dataset announced via ProteomeXchange.

Title	Temporal and sex-linked protein expression dynamics in a familial model of Alzheimer’s Disease
Description	Mouse models of Alzheimer’s Disease (AD), which show progression through various AD stages reflective of human pathology, like 5XFAD, are well established tools for uncovering novel AD related pathways. In addition, they permit temporal examination of the intermingling of AD related pathways and can be used to potentially dissect initiating and propagating events in AD, which are critical for developing biomarkers or designing interventions in early stages of the disease. The present research offers a robust and exhaustive tandem MS examination of a familial AD mice model with a design including variables of: time (three, six, and nine months), genetic background (5XFAD vs. WT), and sex (equal males and females).
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:52:40.756.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD030161
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Filipa Blasco Lopes
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-03 04:48:44	ID requested
1	2022-09-16 06:18:36	announced
⏵ 2	2023-11-14 08:52:41	announced	2023-11-14: Updated project metadata.

10.6019/PXD030161;

submitter keyword: hippocampus,Alzheimer’s disease, Brain, neurodegenerative diseases, temporal, mice, 5XFAD

Mark R. Chance
contact affiliation	Department of Nutrition, Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA; Case Center for Synchrotron Biosciences, Brookhaven National Laboratory, Upton, New York, USA
contact email	mark.chance@case.edu
lab head
Filipa Blasco Lopes
contact affiliation	Case Western Reserve University
contact email	Fxb99@case.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/09/PXD030161

PRIDE project URI

• PRIDE
  1. PXD030161
     1. Label: PRIDE project
     2. Name: Temporal and sex-linked protein expression dynamics in a familial model of Alzheimer’s Disease