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PXD030144

PXD030144 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRequirement of Rbx1 Cullin-RING ligase E3 and Ube2m neddylation E2 in the maintenance of the fitness of Treg cells
Descriptionthe Ube2m-Rbx1 axis is required for the maintenance of homeostasis and functions of Treg cells; and Rbx1 has Ube2m-independent roles in the fitness of Treg cells, suggesting a layer of complexity in neddylation activation of CRLs.
HostingRepositoryiProX
AnnounceDate2021-12-03
AnnouncementXMLSubmission_2022-10-12_19:42:47.420.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMingwei Liu
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-12-02 20:03:35ID requested
12021-12-02 20:07:26announced
22022-10-12 19:42:48announced2022-10-13: Update publication information.
Publication List
Wu D, Li H, Liu M, Qin J, Sun Y, The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness. Nat Commun, 13(1):3021(2022) [pubmed]
Keyword List
submitter keyword: Rbx1, Treg cells, mice
Contact List
Yi Sun
contact affiliationInstitute of Translational Medicine, Zhejiang University School of Medicine
contact emailyisun@zju.edu.cn
lab head
Mingwei Liu
contact affiliationBeijing Proteome Research Center
contact emailmwliu@126.com
dataset submitter
Full Dataset Link List
iProX dataset URI