PXD030136

PXD030136 is an original dataset announced via ProteomeXchange.

Title	Quantitative insights into the contribution of nematocysts to the adaptive success of cnidarians by a proteomic analysis
Description	Nematocysts are secretory organelles in cnidarians that play important roles in predation, de-fense, locomotion, and host invasion. However, the extent to which nematocysts contribute to adaptation and the mechanisms underlying nematocyst evolution are unclear. Here, we inves-tigated the role of the nematocyst in cnidarian evolution based on 8 nematocyst proteomes and 110 cnidarian transcriptomes/genomes. We detected extensive species-specific adaptative muta-tions in nematocyst proteins (NEMs) and evidence for decentralized evolution, in which most evolutionary events involved non-core NEMs, reflecting the rapid diversification of NEMs in cnidarians. Moreover, there was a 33–55 million year macroevolutionary lag between nematocyst evolution and the main phases of cnidarian diversification, suggesting that the nematocyst can act as a driving force in evolution. Quantitative analysis revealed an excess of adaptive changes in NEMs and enrichment for positively selected conserved NEMs. Together, these findings suggest that nematocyst may be key to the adaptive success of cnidarians and provide a reference for quantitative analyses of the roles of phenotypic novelties in adaptation.
HostingRepository	PRIDE
AnnounceDate	2022-02-16
AnnouncementXML	Submission_2022-02-16_09:46:28.473.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	qingxiang Guo
SpeciesList	scientific name: Thelohanellus kitauei; NCBI TaxID: 669202; scientific name: Myxobolus honghuensis; NCBI TaxID: 1085956; scientific name: Myxobolus wulii; NCBI TaxID: 649408;
ModificationList	acetylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-02 08:09:38	ID requested
⏵ 1	2022-02-16 09:46:30	announced

Guo Q, Whipps CM, Zhai Y, Li D, Gu Z, Quantitative Insights into the Contribution of Nematocysts to the Adaptive Success of Cnidarians Based on Proteomic Analysis. Biology (Basel), 11(1):(2022) [pubmed]

submitter keyword: adaptive evolution, phenotypic novelty, cnidarians, myxozoans, nematocysts, toxin

Zemao Gu
contact affiliation	College of Fisheries, Huazhong Agricultural University
contact email	guzemao@mail.hzau.edu.cn
lab head
qingxiang Guo
contact affiliation	Huazhong Agricultural University
contact email	guoqing@webmail.hzau.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD030136

PRIDE project URI

• PRIDE
  1. PXD030136
     1. Label: PRIDE project
     2. Name: Quantitative insights into the contribution of nematocysts to the adaptive success of cnidarians by a proteomic analysis