PXD030093

PXD030093 is an original dataset announced via ProteomeXchange.

Title	Influenza A virus replication in primary human kidney cells reveals regulated cell death as a potential factor for acute kidney injury in influenza
Description	Influenza A virus (IAV) infection can cause the lethal acute respiratory distress syndrome of the lung (ARDS). However, AKI is frequently noticed and correlated to an increased mortality. While the causality for influenza-related ARDS is well established, the pathogenesis of influenza-related AKI is incompletely understood. Yet, in post mortem studies of patients infected with H1N1- or H5N6-type IAV, viral antigen was detected in tubular and glomerular cells. Relevantly, receptors for human and avian IAV are present on human kidney cells, viremia was observed and IAV was repeatedly detected by infectivity- and PCR assays in human urine.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:41:25.599.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shady Amr
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-02 02:08:07	ID requested
1	2024-05-22 11:55:35	announced
⏵ 2	2024-10-22 06:41:31	announced	2024-10-22: Updated project metadata.

Koch B, Shehata M, M, ü, ller-Ruttloff C, Gouda SA, Wetzstein N, Patyna S, Scholz A, Schmid T, Dietrich U, M, ü, nch C, Ziebuhr J, Geiger H, Martinez-Sobrido L, Baer PC, Mostafa A, Pleschka S, Influenza A virus replicates productively in primary human kidney cells and induces factors and mechanisms related to regulated cell death and renal pathology observed in virus-infected patients. Front Cell Infect Microbiol, 14():1363407(2024) [pubmed]

10.3389/fcimb.2024.1363407;

submitter keyword: regulated cell death,acute kidney injury, Influenza A

Christian Münch
contact affiliation	Institute of Biochemistry II - Goethe-Universität Frankfurt am Main
contact email	ch.muench@em.uni-frankfurt.de
lab head
Shady Amr
contact affiliation	Institute of Biochemistry II - Goethe-Universität Frankfurt am Main
contact email	amr@med.uni-frankfurt.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD030093

PRIDE project URI

• PRIDE
  1. PXD030093
     1. Label: PRIDE project
     2. Name: Influenza A virus replication in primary human kidney cells reveals regulated cell death as a potential factor for acute kidney injury in influenza