PXD030067

PXD030067 is an original dataset announced via ProteomeXchange.

Title	LFQ of mouse brain in ischemic stroke
Description	Ischemic disorders are the leading cause of death worldwide. The extracellular signal-regulated kinases 1 and 2 (ERK1/2) are part of the Raf/MEK/ERK1/2 cascade and are thought to affect the outcome of ischemic stroke. However, it is under debate whether activation or inhibition of ERK1/2 is beneficial. Therefore, this study aimed to investigate the impact of ERK1/2 after cerebral ischemia using transgenic mice with ubiquitous overexpression of ERK2 or of the Raf kinase inhibitor protein (RKIP), an inhibitor of the ERK1/2 signaling cascade.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_04:13:31.063.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD030067
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Yvonne Reinders
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-30 08:47:02	ID requested
⏵ 1	2022-02-17 04:13:31	announced

Schanbacher C, Bieber M, Reinders Y, Cherpokova D, Teichert C, Nieswandt B, Sickmann A, Kleinschnitz C, Langhauser F, Lorenz K, ERK1/2 Activity Is Critical for the Outcome of Ischemic Stroke. Int J Mol Sci, 23(2):(2022) [pubmed]

submitter keyword: Brain, LFQ, Mouse

Kristina Lorenz
contact affiliation	Institut für Pharmakologie und Toxikologie Versbacher Straße 9 D-97078 Würzburg Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. Bunsen-Kirchhoff-Str. 11 D-44139 Dortmund
contact email	lorenz@toxi.uni-wuerzburg.de
lab head
Yvonne Reinders
contact affiliation	Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V.
contact email	yvonne.reinders@isas.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD030067

PRIDE project URI

• PRIDE
  1. PXD030067
     1. Label: PRIDE project
     2. Name: LFQ of mouse brain in ischemic stroke