PXD030005

PXD030005 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteomic profiling of D816V-KIT cells
Description	Acute Myeloid Leukaemia (AML) carries a 5 year survival rate of just 24%. Toxic chemotherapy regimens remain the backbone of standard of care for AML. The KIT tyrosine kinase is a recognised AML oncogene, associated with poor outcome. We recently identified DNA-PK as a novel therapeutic target in FLT3 mutant AML. The similarity between KIT and FLT3 regulated signalling pathways led us to investigate DNA-PK in KIT-mutant AML.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:25:31.445.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD030005
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Nicole Verrills
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-28 05:40:15	ID requested
1	2023-01-26 01:54:48	announced
⏵ 2	2023-11-14 07:25:32	announced	2023-11-14: Updated project metadata.

Murray HC, Miller K, Brzozowski JS, Kahl RGS, Smith ND, Humphrey SJ, Dun MD, Verrills NM, Synergistic Targeting of DNA-PK and KIT Signaling Pathways in KIT Mutant Acute Myeloid Leukemia. Mol Cell Proteomics, 22(3):100503(2023) [pubmed]

submitter keyword: Phosphoproteomics, KIT, AML

Nicole Verrills
contact affiliation	School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, and Cancer Research Program, Hunter Medical Research Institute, NSW, 2308, Australia
contact email	Nikki.Verrills@newcastle.edu.au
lab head
Nicole Verrills
contact affiliation	School of Biomedical Sciences and Pharmacy Faculty of Health and Medicine, University of Newcastle, and Cancer Research Program, Hunter Medical Research Institute, Callaghan, NSW, 2308, Australia
contact email	Nikki.Verrills@newcastle.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/01/PXD030005

PRIDE project URI

• PRIDE
  1. PXD030005
     1. Label: PRIDE project
     2. Name: Phosphoproteomic profiling of D816V-KIT cells