PXD029998
PXD029998 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Anoplocephala perfoliata whole somatic proteome |
| Description | Equid tapeworms have previously been considered to be of little pathological importance. Consequently, molecular characterisation of the proteome of Anoplocephala perfoliata has been previously neglected. However, associations with significant intestinal damage and colic cases demonstrate A. perfoliata infections pose a greater risk to equine health than previously considered. In the absence of commercial vaccines, the sole control option for equid tapeworms is via anthelmintic treatment. Limitations in control options pose a risk in anthelmintic resistance development and a reduced ability to sustain control of equid tapeworms. Proteomic analysis and characterisation of glutathione transferases (GST) have shown promise as novel anthelmintic or vaccine targets for improved helminth control. So whole worm proteome was analysed through 1DE and LC-MSMS to localise GST in the whole somatic proteome which may not be purified through GSH columns. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-05-22 |
| AnnouncementXML | Submission_2024-05-22_02:07:30.035.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD029998 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Holly Northcote |
| SpeciesList | scientific name: Anoplocephala perfoliata; NCBI TaxID: 218192; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-11-28 04:59:58 | ID requested | |
| ⏵ 1 | 2024-05-22 02:07:30 | announced |
Publication List
| 10.1017/s0031182024000015; |
| Northcote HM, Wititkornkul B, Cutress DJ, Allen ND, Brophy PM, Wonfor RE, Morphew RM, . Parasitology, 151(3):282-294(2024) [pubmed] |
| 10.6019/PXD029998; |
Keyword List
| submitter keyword: Equine, Tapeworm,LC-MSMS |
Contact List
| Dr Russell Morphew | |
|---|---|
| contact affiliation | IBERS, Aberystwyth University |
| contact email | rom@aber.ac.uk |
| lab head | |
| Holly Northcote | |
| contact affiliation | IBERS, Aberystwyth Univeristy |
| contact email | hmn2@aber.ac.uk |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD029998 |
| PRIDE project URI |
Repository Record List
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