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PXD029970 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDe novo variants of CSNK2B cause a new intellectual disability-craniodigital syndrome by disrupting the canonical Wnt signaling pathway
DescriptionMain purpose of the project is to delineate the consequences of de novo variants identified in patients manifesting intellectual disability-craniodigital syndrome. By employing pulldown assay coupled with mass spectrometry, we investigated the novel binding partners of CK2β and tried to find the impaired interaction due to variant, CK2β:NP_001311.3;p.Asp32His. Furthermore, we also investigated the effects of mutated CK2β by performing phosphoproteome profiling of patient derived LCLs along with the age and gender matched control.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPrerana Wagle
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-11-26 05:13:54ID requested
12022-05-04 03:54:51announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: CSNK2B, CK2β and CK2
Contact List
Muhammad Sajid Hussain
contact affiliationCologne Center for Genomics (CCG), University of Cologne, Faculty of Medicine and University Hospital Cologne (lab head)
contact emailmhussain@uni-koeln.de
lab head
Prerana Wagle
contact affiliationCECAD Research Center
contact emailproteomics-facility@uni-koeln.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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