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PXD029969

PXD029969 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe Phosphorylation Landscape of Interferon-Induced Antiviral Signaling
DescriptionPhosphorylation events act as a fine switch that regulates the proper functioning of the innate immune system upon IFN stimulation. Upon binding of IFN to its receptor, phosphorylation and activation of the Jak/STAT pathway is a very well studied event. However, little is known about the activation of other pathways and the role they play in modulating this powerful antiviral response. This led us to raise the hypothesis that, changes in the phosphorylation status of proteins induced by IFN stimulation can activate novel signaling pathways with an impact on the IFN response. To this end, we have conducted a label-free quantitative phosphoproteomic analysis and identified a new set of proteins that are modified upon IFN treatment, and thereby may represent novel candidates acting at different levels of the IFN response.
HostingRepositoryPRIDE
AnnounceDate2025-03-10
AnnouncementXMLSubmission_2025-03-10_12:17:20.819.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterIdoia Busnadiego
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-11-26 05:07:53ID requested
12025-03-10 12:17:21announced
Publication List
10.1073/PNAS.2412990122;
Keyword List
submitter keyword: Phosphoproteomics, Antiviral factors,Interferon
Contact List
Prof. Dr. Benjamin G. Hale
contact affiliationInstitute of Medical Virology. University of Zurich
contact emailhale.ben@virology.uzh.ch
lab head
Idoia Busnadiego
contact affiliationInstitute of Medical Virology. University of Zurich
contact emailidoiabusnadiego@gmail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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