PXD029969

PXD029969 is an original dataset announced via ProteomeXchange.

Title	The Phosphorylation Landscape of Interferon-Induced Antiviral Signaling
Description	Phosphorylation events act as a fine switch that regulates the proper functioning of the innate immune system upon IFN stimulation. Upon binding of IFN to its receptor, phosphorylation and activation of the Jak/STAT pathway is a very well studied event. However, little is known about the activation of other pathways and the role they play in modulating this powerful antiviral response. This led us to raise the hypothesis that, changes in the phosphorylation status of proteins induced by IFN stimulation can activate novel signaling pathways with an impact on the IFN response. To this end, we have conducted a label-free quantitative phosphoproteomic analysis and identified a new set of proteins that are modified upon IFN treatment, and thereby may represent novel candidates acting at different levels of the IFN response.
HostingRepository	PRIDE
AnnounceDate	2025-03-10
AnnouncementXML	Submission_2025-03-10_12:17:20.819.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Idoia Busnadiego
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-26 05:07:53	ID requested
⏵ 1	2025-03-10 12:17:21	announced

10.1073/PNAS.2412990122;

submitter keyword: Phosphoproteomics, Antiviral factors,Interferon

Prof. Dr. Benjamin G. Hale
contact affiliation	Institute of Medical Virology. University of Zurich
contact email	hale.ben@virology.uzh.ch
lab head
Idoia Busnadiego
contact affiliation	Institute of Medical Virology. University of Zurich
contact email	idoiabusnadiego@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD029969

PRIDE project URI

• PRIDE
  1. PXD029969
     1. Label: PRIDE project
     2. Name: The Phosphorylation Landscape of Interferon-Induced Antiviral Signaling