PXD029969 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The Phosphorylation Landscape of Interferon-Induced Antiviral Signaling |
Description | Phosphorylation events act as a fine switch that regulates the proper functioning of the innate immune system upon IFN stimulation. Upon binding of IFN to its receptor, phosphorylation and activation of the Jak/STAT pathway is a very well studied event. However, little is known about the activation of other pathways and the role they play in modulating this powerful antiviral response. This led us to raise the hypothesis that, changes in the phosphorylation status of proteins induced by IFN stimulation can activate novel signaling pathways with an impact on the IFN response. To this end, we have conducted a label-free quantitative phosphoproteomic analysis and identified a new set of proteins that are modified upon IFN treatment, and thereby may represent novel candidates acting at different levels of the IFN response. |
HostingRepository | PRIDE |
AnnounceDate | 2025-03-10 |
AnnouncementXML | Submission_2025-03-10_12:17:20.819.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Idoia Busnadiego |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-11-26 05:07:53 | ID requested | |
⏵ 1 | 2025-03-10 12:17:21 | announced | |
Publication List
Keyword List
submitter keyword: Phosphoproteomics, Antiviral factors,Interferon |
Contact List
Prof. Dr. Benjamin G. Hale |
contact affiliation | Institute of Medical Virology. University of Zurich |
contact email | hale.ben@virology.uzh.ch |
lab head | |
Idoia Busnadiego |
contact affiliation | Institute of Medical Virology. University of Zurich |
contact email | idoiabusnadiego@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD029969
- Label: PRIDE project
- Name: The Phosphorylation Landscape of Interferon-Induced Antiviral Signaling