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PXD029924

PXD029924 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleKOPI - Kinase inhibitor proteome impact analysis
DescriptionKinase inhibitors often exhibit on/off-target effects, and efficient data analysis is essential for assessing these effects on the proteome. We developed a workflow for rapidly performing such a proteomic assessment, termed as kinase inhibitor proteome impact analysis (KOPI). We demonstrate KOPI’s utility with staurosporine on the leukemic K562 cell proteome. We analysed the changes in the proteome, thermal stability and phosphoproteome in the cells response to staurosporine. We identified systemically staurosporine’s non-kinome interactors, and showed for the first time that it caused paradoxical hyper- and biphasic phosphorylation.
HostingRepositoryjPOST
AnnounceDate2022-06-16
AnnouncementXMLSubmission_2023-04-02_20:19:10.180.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRadoslaw Sobota
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListS-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; O-phospho-L-serine; O-phospho-L-threonine; O4'-phospho-L-tyrosine; alpha-amino acetylated residue; deamidated L-glutamine; deamidated L-asparagine
Instrumentinstrument
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-11-26 01:31:52ID requested
12022-06-16 06:31:38announced
22022-09-18 02:36:10announced2022-09-18: Updated FTP location.
32023-04-02 20:19:11announced2023-04-03: Updated PubMed.
Publication List
Li GX, Zhao T, Wang LC, Choi H, Lim YT, Sobota RM, KOPI: Kinase inhibitOr Proteome Impact analysis. Sci Rep, 12(1):13015(2022) [pubmed]
Keyword List
submitter keyword: TMT, CETSA, protein expression, phosphorylation
Contact List
Lim Yan Ting, Radoslaw Sobota
lab head
Radoslaw Sobota
contact affiliationIMCB A-STAR Singapore
dataset submitter
Full Dataset Link List
jPOST dataset URI
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST001389/