A bleomycin induced-pulmonary fibrosis mouse model was established. C57BL/6J male mice were divided into 4 groups: the control group, model group, moxibustion group, and YQHX group. Mice were anesthetized firstly. Then, 2.5 mg/kg of bleomycin was instilled through the airways into the lungs of the model, moxibustion and YQHX groups. Control group mice received the same volume of saline. Seven days later, YQHX group mice were treated with YQHX (50 mg/kg) daily by gavage for 2 weeks. The control and model group received the same volume of saline. Moxibustion group received moxibustion treatment for 2 weeks. At last, all mice were euthanized and their lungs were removed for proteomic test.